Περίληψη:
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10 â'8), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci - 9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1∗1301-HLA-DQA1∗0103-HLA-DQB1∗0603 (odds ratio (OR) = 0.59, P = 2.7 × 10-9). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10-6) than in HPV-negative (OR = 0.75, P = 0.16) cancers. © 2016 Nature America, Inc. part of Springer Nature, All Rights reserved.
Συγγραφείς:
Lesseur, C.
Diergaarde, B.
Olshan, A.F.
Wünsch-Filho, V.
Ness, A.R.
Liu, G.
Lacko, M.
Eluf-Neto, J.
Franceschi, S.
Lagiou, P.
Macfarlane, G.J.
Richiardi, L.
Boccia, S.
Polesel, J.
Kjaerheim, K.
Zaridze, D.
Johansson, M.
Menezes, A.M.
Curado, M.P.
Robinson, M.
Ahrens, W.
Canova, C.
Znaor, A.
Castellsagué, X.
Conway, D.I.
Holcátová, I.
Mates, D.
Vilensky, M.
Healy, C.M.
Szeszenia-Dabrowska, N.
Fabiánová, E.
Lissowska, J.
Grandis, J.R.
Weissler, M.C.
Tajara, E.H.
Nunes, F.D.
De Carvalho, M.B.
Thomas, S.
Hung, R.J.
Peters, W.H.M.
Herrero, R.
Cadoni, G.
Bueno-De-Mesquita, H.B.
Steffen, A.
Agudo, A.
Shangina, O.
Xiao, X.
Gaborieau, V.
Chabrier, A.
Anantharaman, D.
Boffetta, P.
Amos, C.I.
McKay, J.D.
Brennan, P.
