Τίτλος:
Human papilloma virus: Apprehending the link with carcinogenesis and unveiling new research avenues (Review)
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Human papilloma viruses (HPV) are a small group of non-enveloped viruses belonging to the Papillomaviridae family with strong similarities to polyoma viruses. The viral particles consist of a genome in the form of a circular double-stranded DNA, encompassing eight open reading frames, as well as a non-enveloped icosahedral capsid. HPV infection is considered the most common sexually transmitted disease in both sexes and is strongly implicated in the pathogenesis of different types of cancer. 'High-risk' mucosal HPV types, predominantly types 16, 18, 31, 33 and 35, are associated with most cervical, penile, vulvar, vaginal, anal, oropharyngeal cancers and pre-cancers. Screening for HPV is necessary for the prognosis and for determining treatment strategies for cancer. Novel HPV markers, including proteomic and genomic markers, as well as anti-papillomavirus vaccines are currently available. The aim of this comprehensive review was to thoroughly present the updated information on virus development, cancer occurrence, treatment and prevention strategies, in an attempt to shed further light into the field, including novel research avenues.
Συγγραφείς:
Boda, D.
Docea, A.O.
Calina, D.
Ilie, M.A.
Caruntu, C.
Zurac, S.
Neagu, M.
Constantin, C.
Branisteanu, D.E.
Voiculescu, V.
Mamoulakis, C.
Tzanakakis, G.
Spandidos, D.A.
Drakoulis, N.
Tsatsakis, A.M.
Περιοδικό:
INTERNATIONAL JOURNAL OF ONCOLOGY
Εκδότης:
Spandidos Publications
Λέξεις-κλειδιά:
biological marker; DNA methyltransferase; long untranslated RNA; protein p53; virus DNA; Wart virus vaccine; biological marker; Wart virus vaccine, cancer control; cancer incidence; cancer prognosis; cancer risk; carcinogenesis; chlamydiasis; disease association; DNA methylation; E6 gene; E7 gene; enzyme linked immunosorbent assay; flow cytometry; genomics; head and neck cancer; Hepatitis C virus; Herpes simplex virus 2; Human papillomavirus type 16; Human papillomavirus type 18; infection prevention; infection sensitivity; matrix assisted laser desorption ionization time of flight mass spectrometry; mixed infection; oncogene; oropharynx cancer; oxidative stress; papillomavirus infection; penis carcinoma; priority journal; protein microarray; proteomics; reverse transcription polymerase chain reaction; Review; sexually transmitted disease; squamous cell carcinoma; tumor suppressor gene; two dimensional electrophoresis; uterine cervix cancer; uterine cervix carcinoma in situ; virogenesis; virus gene; virus load; virus transmission; Wart virus; early cancer diagnosis; epithelium; female; human; incidence; isolation and purification; male; neoplasm; Papillomaviridae; papillomavirus infection; pathogenicity; procedures; sex factor; sexually transmitted disease; virology, Biomarkers; Carcinogenesis; Early Detection of Cancer; Epithelium; Female; Humans; Incidence; Male; Neoplasms; Papillomaviridae; Papillomavirus Infections; Papillomavirus Vaccines; Proteomics; Sex Factors; Sexually Transmitted Diseases, Viral
DOI:
10.3892/ijo.2018.4256
