Περίληψη:
The randomized phase 3 ENDEAVOR study (N=929) compared carfilzomib and dexamethasone (Kd) with bortezomib and dexamethasone (Vd) in relapsed multiple myeloma (RMM). We performed a subgroup analysis from ENDEAVOR in patients categorized by number of prior lines of therapy or by prior treatment. Median progression-free survival (PFS) for patients with one prior line was 22.2 months for Kd vs 10.1 months for Vd, and median PFS for patients with ≥2 prior lines was 14.9 months for Kd vs 8.4 months for Vd. For patients with prior bortezomib exposure, the median PFS was 15.6 months for Kd vs 8.1 months for Vd, and for patients with prior lenalidomide exposure the median PFS was 12.9 months for Kd vs 7.3 months for Vd. Overall response rates (Kd vs Vd) were 81.9 vs 65.5% (one prior line), 72.0 vs 59.7% (≥2 prior lines), 71.2 vs 60.3% (prior bortezomib) and 70.1 vs 59.3% (prior lenalidomide). The safety profile in the prior lines subgroups was qualitatively similar to that in the broader ENDEAVOR population. In RMM, outcomes are improved when receiving treatment with carfilzomib compared with bortezomib, regardless of the number of prior therapy lines or prior exposure to bortezomib or lenalidomide. © 2017 Macmillan Publishers Limited, part of Springer Nature.
Συγγραφείς:
Moreau, P.
Joshua, D.
Chng, W.-J.
Palumbo, A.
Goldschmidt, H.
Hájek, R.
Facon, T.
Ludwig, H.
Pour, L.
Niesvizky, R.
Oriol, A.
Rosiñol, L.
Suvorov, A.
Gaidano, G.
Pika, T.
Weisel, K.
Goranova-Marinova, V.
Gillenwater, H.H.
Mohamed, N.
Aggarwal, S.
Feng, S.
Dimopoulos, M.A.
Λέξεις-κλειδιά:
bortezomib; carfilzomib; dexamethasone; lenalidomide; antineoplastic agent; bortezomib; carfilzomib; dexamethasone; oligopeptide, adult; anemia; Article; cancer combination chemotherapy; cancer patient; cancer recurrence; cancer survival; controlled study; diarrhea; drug efficacy; drug exposure; drug safety; dyspnea; fatigue; heart failure; human; hypertension; intention to treat analysis; kidney failure; lymphocyte count; lymphocytopenia; major clinical study; multiple cycle treatment; multiple myeloma; neutropenia; peripheral neuropathy; phase 3 clinical trial; pneumonia; priority journal; progression free survival; randomized controlled trial; side effect; thrombocyte count; thrombocytopenia; treatment outcome; treatment response; aged; clinical trial; disease free survival; middle aged; mortality; multiple myeloma; procedures; recurrent disease; salvage therapy; very elderly, Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Dexamethasone; Disease-Free Survival; Humans; Middle Aged; Multiple Myeloma; Oligopeptides; Recurrence; Salvage Therapy; Treatment Outcome
