Τίτλος:
Effects of newer antidiabetic drugs on endothelial function and arterial stiffness: A systematic review and meta-analysis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background. Newer antidiabetic drugs, i.e., dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may exert distinct cardiovascular effects. We sought to explore their impact on vascular function. Methods. Published literature was systematically searched up to January 2018 for clinical studies assessing the effects of DPP-4 inhibitors, GLP-1 RAs, and SGLT-2 inhibitors on endothelial function and arterial stiffness, assessed by flow-mediated dilation (FMD) of the brachial artery and pulse wave velocity (PWV), respectively. For each eligible study, we used the mean difference (MD) with 95% confidence intervals (CIs) for FMD and PWV. The pooled MD for FMD and PWV were calculated by using a random-effect model. The presence of heterogeneity among studies was evaluated by the I 2 statistic. Results. A total of 26 eligible studies (n = 668 patients) were included in the present meta-analysis. Among newer antidiabetic drugs, only SGLT-2 inhibitors significantly improved FMD (pooled MD 1.14%, 95% CI: 0.18 to 1.73, p = 0 016), but not DPP-4 inhibitors (pooled MD = 0.86%, 95% CI: -0.15 to 1.86, p = 0 095) or GLP-1 RA (pooled MD = 2.37%, 95% CI: -0.51 to 5.25, p = 0 107). Both GLP-1 RA (pooled MD = −1.97, 95% CI: -2.65 to -1.30, p < 0 001) and, to a lesser extent, DPP-4 inhibitors (pooled MD = -0.18, 95% CI: -0.30 to -0.07, p = 0 002) significantly decreased PWV. Conclusions. Newer antidiabetic drugs differentially affect endothelial function and arterial stiffness, as assessed by FMD and PWV, respectively. These findings could explain the distinct effects of these drugs on cardiovascular risk of patients with type 2 diabetes. Copyright © 2018 Konstantinos Batzias et al.
Συγγραφείς:
Batzias, K.
Antonopoulos, A.S.
Oikonomou, E.
Siasos, G.
Bletsa, E.
Stampouloglou, P.K.
Mistakidi, C.-V.
Noutsou, M.
Katsiki, N.
Karopoulos, P.
Charalambous, G.
Thanopoulou, A.
Tentolouris, N.
Tousoulis, D.
Περιοδικό:
Journal of Diabetes Research
Λέξεις-κλειδιά:
alogliptin; dapagliflozin; dipeptidyl peptidase IV; dipeptidyl peptidase IV inhibitor; dulaglutide; dutogliptin; evogliptin; exendin 4; gemigliptin; glucagon like peptide 1; glucagon like peptide 1 receptor; glucagon like peptide 1 receptor agonist; linagliptin; liraglutide; lixisenatide; omarigliptin; saxagliptin; semaglutide; sitagliptin; sodium glucose cotransporter 2; sodium glucose cotransporter 2 inhibitor; teneligliptin; trelagliptin; vildagliptin; antidiabetic agent; dipeptidyl peptidase IV inhibitor, arterial stiffness; blood vessel function; brachial artery; cardiovascular risk; clinical assessment; clinical evaluation; drug effect; endothelium; flow-mediated dilation test; human; meta analysis; outcome assessment; publication bias; pulse wave; quality control; quantitative analysis; Review; systematic review; animal; arterial stiffness; diet therapy; drug therapy; non insulin dependent diabetes mellitus; pathophysiology; pharmacology; vascular endothelium, Animals; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Endothelium, Vascular; Humans; Hypoglycemic Agents; Sodium-Glucose Transporter 2 Inhibitors; Vascular Stiffness
DOI:
10.1155/2018/1232583
