Τίτλος:
Neuroendocrine neoplasms of the appendix: A review of the literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Appendiceal neuroendocrine neoplasms (ANENs) comprise rare tumors of the appendix, mainly affecting young populations and characterized by a rather favorable prognosis. The aim of this review was to summarize the current knowledge on these neoplasms, focusing on the management and followup of such patients, which still remain under debate. ANENs account for 0.16-2.3% of appendectomies and are usually diagnosed incidentally. The histopathological diagnosis includes the immunohistochemical profile of the tumor in regard to synaptophysin and chromogranin A, as well as the Ki-67 index. The surgical management of ANENs is either simple appendectomy or a more extensive oncological operation including right hemicolectomy. This depends on the stage and the presence of risk factors suggesting a more aggressive disease, such as the exact location, mesoappendiceal or lymphovascular invasion, and the proliferative rate of the tumor. Despite their indolent course, ANENs may relapse. Therefore, lifetime observation is necessary for patients with tumors >2 cm and >1 cm plus additional risk factors; however, more studies should be conducted in order to determine the optimal follow-up strategy. © 2018 International Institute of Anticancer Research. All Right Reserved.
Συγγραφείς:
Tsilimigras, D.I.
Vagios, S.
Ntanasis-Stathopoulos, I.
Karachaliou, G.-S.
Papalampros, A.
Alexandrou, A.
Blazer, D.G., 3RD
Felekouras, E.
Moris, D.
Περιοδικό:
ANTICANCER RESEARCH
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
chromogranin A; Ki 67 antigen; synaptophysin, appendectomy; appendix cancer; cancer diagnosis; cancer localization; cancer prognosis; cancer recurrence; cancer surgery; cancer survival; follow up; hemicolectomy; histopathology; human; immunohistochemistry; lymph vessel metastasis; mesoappendiceal invasion; neuroendocrine carcinoma; pathogenesis; priority journal; Review; risk factor; tumor invasion; appendix tumor; neuroendocrine tumor; pathology; prognosis, Appendectomy; Appendiceal Neoplasms; Humans; Neuroendocrine Tumors; Prognosis
DOI:
10.21873/anticanres.12264
