Τίτλος:
Epithelial-mesenchymal transition in non small-cell lung cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aim: Lung cancer is the first cause of cancer related deaths in both males and females. Epithelial-mesenchymal transition (EMT) is a reversible process by which epithelial cells transform to mesenchymal stem cells by losing their cell polarity and cell-to-cell adhesion, gaining migratory and invasive properties. High levels of E-cadherin are expressed in epithelial cells, whereas mesenchymal cells express high levels of N-cadherin, fibronectin and vimentin. The aim of this study was to evaluate the correlation between E-cadherin and vimentin expression and their clinical significance in non-small cell lung cancer (NSCLC). Materials and Methods: The immunohistochemical expression of E-cadherin, vimentin and Ki-67 was performed on tissue microarrays from NSCLC specimens obtained from 112 newly-diagnosed cases and were studied using classical pathological evaluation. Associations between E-cadherin, vimentin and Ki-67 expression, clinicopathological variables and survival were analyzed. In all cases, a value of p=0.05 was considered significant. Results: Low E-cadherin expression was significantly correlated with tumor necrosis (p=0.019). Moreover, there was a trend for correlation between high E-cadherin expression and better overall survival (hazard ratio=1.02, and 95% confidence interval=0.45-1.87, p=0.091). There was also a significant negative correlation between vimentin expression and overall survival (hazard ratio=1.13, and 95% confidence interval=0.78-1.65, p=0.026). Additionally, there was a significant negative correlation between vimentin expression and grade I tumors (p=0.031). Finally, a positive correlation trend between vimentin expression and Ki-67 was found (p=0.073). Conclusion: High E-cadherin and low vimentin expression correlate with better prognosis and overall survival.
Συγγραφείς:
Tsoukalas, N.
Aravantinou-Fatorou, E.
Tolia, M.
Giaginis, C.
Galanopoulos, M.
Kiakou, M.
Kostakis, I.D.
Dana, E.
Vamvakaris, I.
Korogiannos, A.
Tsiambas, E.
Salemis, N.
Kyrgias, G.
Karameris, A.
Theocharis, S.
Περιοδικό:
ANTICANCER RESEARCH
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
Ki 67 antigen; uvomorulin; vimentin; cadherin; CDH1 protein, human; fibronectin; FN1 protein, human; tumor marker; vimentin, adult; aged; Article; cancer survival; controlled study; correlation analysis; epithelial mesenchymal transition; evaluation study; female; human; major clinical study; male; non small cell lung cancer; overall survival; priority journal; protein expression; tissue microarray; tumor necrosis; adenocarcinoma; cancer staging; enzyme immunoassay; follow up; large cell carcinoma; lung tumor; metabolism; middle aged; non small cell lung cancer; pathology; prognosis; squamous cell carcinoma; survival rate; tumor invasion; very elderly, Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cadherins; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Epithelial-Mesenchymal Transition; Female; Fibronectins; Follow-Up Studies; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Survival Rate; Tissue Array Analysis; Vimentin
DOI:
10.21873/anticanres.11510
