Περίληψη:
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.26; 95% CI 1.00–1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.29; 95% CI 1.02–1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation. © 2016 UICC
Συγγραφείς:
Matejcic, M.
de Batlle, J.
Ricci, C.
Biessy, C.
Perrier, F.
Huybrechts, I.
Weiderpass, E.
Boutron-Ruault, M.C.
Cadeau, C.
His, M.
Cox, D.G.
Boeing, H.
Fortner, R.T.
Kaaks, R.
Lagiou, P.
Trichopoulou, A.
Benetou, V.
Tumino, R.
Panico, S.
Sieri, S.
Palli, D.
Ricceri, F.
Bueno-de-Mesquita, H.B.
Skeie, G.
Amiano, P.
Sánchez, M.J.
Chirlaque, M.D.
Barricarte, A.
Quirós, J.R.
Buckland, G.
van Gils, C.H.
Peeters, P.H.
Key, T.J.
Riboli, E.
Gylling, B.
Zeleniuch-Jacquotte, A.
Gunter, M.J.
Romieu, I.
Chajès, V.
Λέξεις-κλειδιά:
5,10 methylenetetrahydrofolate reductase (FADH2); adenine; cyanocobalamin; cytosine; epidermal growth factor receptor 2; estrogen receptor; folic acid; progesterone receptor; thymine; biological marker; cyanocobalamin; estrogen; folic acid; methylenetetrahydrofolate reductase (NADPH2); MTHFR protein, human; progesterone, adult; aged; alcohol consumption; Article; blood sampling; breast cancer; cancer risk; cohort analysis; controlled study; cyanocobalamin blood level; DNA polymorphism; female; folic acid blood level; genetic association; human; major clinical study; menopause; MTHFR gene; population based case control study; prospective study; risk assessment; vitamin blood level; adverse effects; blood; Breast Neoplasms; case control study; chemistry; clinical trial; diet; drinking behavior; Europe; folic acid deficiency; follow up; genetics; lifestyle; middle aged; multicenter study; Neoplasms, Hormone-Dependent; proto oncogene; risk factor; single nucleotide polymorphism; Vitamin B 12 Deficiency, Adult; Aged; Alcohol Drinking; Biomarkers; Breast Neoplasms; Case-Control Studies; Diet; Estrogens; Europe; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Genes, erbB-2; Humans; Life Style; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasms, Hormone-Dependent; Polymorphism, Single Nucleotide; Progesterone; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency
