Περίληψη:
We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated the association between prediagnostic circulating OPN levels and HCC incidence in a large population-based cohort. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. During a mean follow-up of 4.8 years, 100 HCC cases were identified. Each case was matched to two controls and OPN levels were measured in baseline plasma samples. Viral hepatitis, liver function, and a-fetoprotein (AFP) tests were also conducted. Conditional logistic regression models were used to calculate multivariable odds ratio (OR) and 95% confidence intervals (95% CI) for OPN levels in relation to HCC. Receiver operating characteristics curves were constructed to determine the discriminatory accuracy of OPN alone or in combination with other liver biomarkers in the prediction of HCC. OPN levels were positively associated with HCC risk (per 10% increment, ORmultivariable = 1.30; 95% CI, 1.14-1.48). The association was stronger among cases diagnosed within 2 years of follow-up. Adding liver function tests to OPN improved the discriminatory performance for subjects who developed HCC (AUC = 0.86). For cases diagnosed within 2 years, the combination of OPN and AFP was best able to predict HCC risk (AUC = 0.88). The best predictive model for HCC in this low-risk population is OPN in combination with liver function tests. Within 2 years of diagnosis, the combination of OPN and AFP best predicted HCC development, suggesting that measuring OPN and AFP could identify high-risk groups independently of a liver disease diagnosis. © 2016 American Association for Cancer Research.
Συγγραφείς:
Duarte-Salles, T.
Misra, S.
Stepien, M.
Plymoth, A.
Muller, D.
Overvad, K.
Olsen, A.
Tjønneland, A.
Baglietto, L.
Severi, G.
Boutron-Ruault, M.-C.
Turzanski-Fortner, R.
Kaaks, R.
Boeing, H.
Aleksandrova, K.
Trichopoulou, A.
Lagiou, P.
Bamia, C.
Pala, V.
Palli, D.
Mattiello, A.
Tumino, R.
Naccarati, A.
Bueno-De-Mesquita, H.B.
Peeters, P.H.
Weiderpass, E.
Quiros, J.R.
Agudo, A.
Sanchez-Cantalejo, E.
Ardanaz, E.
Gavrila, D.
Dorronsoro, M.
Werner, M.
Hemmingsson, O.
Ohlsson, B.
Sjöberg, K.
Wareham, N.J.
Khaw, K.-T.
Bradbury, K.E.
Gunter, M.J.
Cross, A.J.
Riboli, E.
Jenab, M.
Hainaut, P.
Beretta, L.
Λέξεις-κλειδιά:
alanine aminotransferase; albumin; alkaline phosphatase; alpha fetoprotein; aspartate aminotransferase; bilirubin; biological marker; C reactive protein; gamma glutamyltransferase; osteopontin; tumor marker; alpha fetoprotein; osteopontin; SPP1 protein, human; tumor marker, adult; aged; alanine aminotransferase blood level; albumin blood level; alkaline phosphatase blood level; alpha fetoprotein blood level; Article; aspartate aminotransferase blood level; bilirubin blood level; cancer incidence; cancer risk; cohort analysis; confidence interval; controlled study; correlation analysis; diagnostic accuracy; early cancer diagnosis; European; female; follow up; gamma glutamyl transferase blood level; high risk patient; human; liver cell carcinoma; liver function; liver function test; logistic regression analysis; low risk population; major clinical study; male; odds ratio; patient identification; population based case control study; prediction; predictive value; priority journal; protein blood level; receiver operating characteristic; risk assessment; virus hepatitis; area under the curve; blood; Carcinoma, Hepatocellular; case control study; Europe; incidence; Liver Neoplasms; middle aged; procedures; very elderly; young adult, Adult; Aged; Aged, 80 and over; alpha-Fetoproteins; Area Under Curve; Biomarkers, Tumor; Carcinoma, Hepatocellular; Case-Control Studies; Early Detection of Cancer; Europe; Female; Humans; Incidence; Liver Neoplasms; Male; Middle Aged; Odds Ratio; Osteopontin; ROC Curve; Young Adult
