Τίτλος:
Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Non-enzymatic protein modifications occur inevitably in all living systems. Products of such modifications accumulate during aging of cells and organisms and may contribute to their age-related functional deterioration. This review presents the formation of irreversible protein modifications such as carbonylation, nitration and chlorination, modifications by 4-hydroxynonenal, removal of modified proteins and accumulation of these protein modifications during aging of humans and model organisms, and their enhanced accumulation in age-related brain diseases. © 2018, Gonos et al.
Συγγραφείς:
Gonos, E.S.
Kapetanou, M.
Sereikaite, J.
Bartosz, G.
Naparlo, K.
Grzesik, M.
Sadowska-Bartosz, I.
Περιοδικό:
Aging (Albany NY)
Εκδότης:
Impact Journals, LLC
Λέξεις-κλειδιά:
aging; animal; brain disease; halogenation; human; metabolism; oxidative stress; pathophysiology; physiology; protein carbonylation; protein processing, Aging; Animals; Brain Diseases; Halogenation; Humans; Oxidative Stress; Protein Carbonylation; Protein Processing, Post-Translational
DOI:
10.18632/aging.101450
