Περίληψη:
Non-small cell lung cancer constitutes the most common type of lung cancer, accounting for 85-90% of lung cancer, and is a leading cause of cancer-related death. Despite the progress during the past years, poor prognosis remains a challenge and requires further research and development of novel antitumor treatment. Recently, the role of histone deacetylases in gene expression has emerged showing their regulation of the acetylation of histone proteins and other non-histone protein targets and their role in chromatin organization, while their inhibitors, the histone deacetylase inhibitors, have been proposed to have a potential therapeutic role in diverse malignancies, including non-small cell lung cancer. This review article focuses on the role of histone deacetylase inhibitors in the treatment of non-small cell lung cancer and the major molecular mechanisms underlying their antitumor activity recognized so far.
Συγγραφείς:
Damaskos, C.
Tomos, I.
Garmpis, N.
Karakatsani, A.
Dimitroulis, D.
Garmpi, A.
Spartalis, E.
Kampolis, C.F.
Tsagkari, E.
Loukeri, A.A.
Margonis, G.-A.
Spartalis, M.
Andreatos, N.
Schizas, D.
Kokkineli, S.
Antoniou, E.A.
Nonni, A.
Tsourouflis, G.
Markatos, K.
Kontzoglou, K.
Kostakis, A.
Tomos, P.
Λέξεις-κλειδιά:
antineoplastic agent; belinostat; histone deacetylase 1; histone deacetylase 2; histone deacetylase 3; histone deacetylase 6; histone deacetylase 7; histone deacetylase inhibitor; panobinostat; trichostatin A; valproic acid; vorinostat; antineoplastic agent; histone deacetylase inhibitor, antineoplastic activity; cancer therapy; drug mechanism; histone acetylation; human; non small cell lung cancer; priority journal; Review; enzymology; lung tumor; non small cell lung cancer, Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Histone Deacetylase Inhibitors; Humans; Lung Neoplasms
