Τίτλος:
p16, HPV, and cetuximab: What is the evidence?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. It has recently been appreciated that human papillomavirus (HPV) status (or p16 status, which is a frequently used surrogate for HPV status) is prognostic for oropharyngeal SCCHN. Here, we review and contextualize existing p16 and HPV data, focusing on the cetuximab registration trials in previously untreated, locoregionally advanced, nonmetastatic SCCHN (LA SCCHN) and in recurrent and/or metastatic SCCHN (R/M SCCHN): the IMCL-9815 and EXTREME clinical trials, respectively. Taken together, the available data suggest that, while p16 and HPV are prognostic biomarkers in patients with LA SCCHN and R/M SCCHN, it could not be shown that they are predictive for the outcomes of the described cetuximab-containing trial regimens. Consequently, although HPV status provides prognostic information, it is not shown to predict therapy response, and so is not helpful for assigning first-line therapy in patients with SCCHN. In addition, we discuss assays currently used to assess p16 and HPV status, as well as the differentiation between these two biomarkers. Ultimately, we believe HPV E6/E7 polymerase chain reaction–based mRNA testing may represent the most informative technique for assessing HPV status in patients with SCCHN.While p16 is a valid surrogate for HPV status in oropharyngeal carcinoma (OPC), there is a higher risk of discordance between p16 and HPVstatus in non-OPC SCCHN. Collectively, these discussions hold key implications for the clinical management of SCCHN. © AlphaMed Press.
Συγγραφείς:
Bonner, J.A.
Mesia, R.
Giralt, J.
Psyrri, A.
Keilholz, U.
Rosenthal, D.I.
Beier, F.
Schulten, J.
Vermorken, J.B.
Περιοδικό:
The oncologist
Λέξεις-κλειδιά:
cetuximab; fluorouracil; panitumumab; platinum; protein p16; retinoblastoma protein; cetuximab; cyclin dependent kinase inhibitor 2A; immunological antineoplastic agent; tumor marker, Article; clinical trial (topic); head and neck squamous cell carcinoma; human; immunohistochemistry; in situ hybridization; oropharynx carcinoma; polymerase chain reaction; priority journal; protein expression; sensitivity and specificity; Wart virus; complication; head and neck tumor; metabolism; papillomavirus infection; pathology; prognosis; squamous cell carcinoma; virology, Antineoplastic Agents, Immunological; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cetuximab; Cyclin-Dependent Kinase Inhibitor p16; Head and Neck Neoplasms; Humans; Papillomavirus Infections; Prognosis
DOI:
10.1634/theoncologist.2016-0433
