Τίτλος:
Late-onset nivolumab-mediated pneumonitis in a patient with melanoma and multiple immune-related adverse events
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Immune-related adverse effects (AEs) of PD-1 inhibitors can affect almost every organ, but the skin, intestine, lung, eye, and liver are the most commonly affected organs. Here, we present the case of a 62-year-old female patient with stage IIIc melanoma treated with nivolumab in an adjuvant setting who sequentially developed hyperthyroidism, hypothyroidism, acute hepatitis, and pneumonitis. Six months before the emergence of pneumonitis, the patient had discontinued treatment with nivolumab because of acute hepatitis. Information on pneumonitis after nivolumab discontinuation in the literature is scarce, whereas most of the cases emerge during the first 2.5 months of treatment. Patients with multiple immune-related AEs comprise a group of special interest as the identification of factors affecting the susceptibility of patients to immune-related AEs of PD-1 inhibitors may lead to a more rational use of these drugs. Human leukocyte antigen haplotype and Fcγ receptor polymorphisms are possible targets of the relevant research. © 2017 Wolters Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
DIamantopoulos, P.T.
Gaggadi, M.
Kassi, E.
Benopoulou, O.
Anastasopoulou, A.
Gogas, H.
Περιοδικό:
Melanoma Research
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
acetylsalicylic acid; alkaline phosphatase; aspartate aminotransferase; atorvastatin; B Raf kinase; bilirubin; carvedilol; Fc receptor; gamma glutamyltransferase; HLA antigen; lactate dehydrogenase; moxifloxacin; nivolumab; prednisone; spironolactone; thiamazole; thyrotropin; antineoplastic agent; monoclonal antibody; nivolumab, acute hepatitis; adult; alkaline phosphatase blood level; Article; aspartate aminotransferase blood level; bilirubin blood level; brain radiography; brain surgery; bronchoscopy; cancer staging; case report; clinical examination; computer assisted tomography; coronary artery disease; coughing; drug dose titration; dyspnea; female; follow up; gamma glutamyl transferase blood level; haplotype; hospital patient; hospitalization; human; hyperthyroidism; hypothyroidism; hypoxia; in-transit metastasis; jaundice; laboratory test; lactate dehydrogenase blood level; lung lavage; malaise; medical history; medical information; melanoma; middle aged; nausea; oxygen therapy; pneumonia; priority journal; thorax radiography; thyrotropin blood level; tonic clonic seizure; treatment duration; ulcer; chemically induced; melanoma; pathology; pneumonia; skin tumor, Antibodies, Monoclonal; Antineoplastic Agents; Female; Humans; Melanoma; Middle Aged; Pneumonia; Skin Neoplasms
DOI:
10.1097/CMR.0000000000000355
