Τίτλος:
Dietary total antioxidant capacity in relation to endometrial cancer risk: a case–control study in Italy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: To investigate the role of the overall antioxidant activity of diet, we estimated the relation between three dietary indices of total antioxidant capacity (TAC) and endometrial cancer risk Methods: We analyzed data from an Italian case–control study including 454 women with incident, histologically confirmed endometrial cancer, and 908 frequency-matched controls admitted to the same hospitals as cases for acute non-neoplastic conditions. A reproducible and valid food frequency questionnaire was used to assess subjects’ habitual diet. TAC was measured using Italian food composition tables in terms of Ferric-reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), and total radical-trapping antioxidant parameter (TRAP). We computed odds ratios (OR) and corresponding 95 % confidence intervals (CIs) using conditional multiple logistic regression models, including terms for recognized endometrial cancer risk factors and total energy intake. Results: TAC was inversely related to endometrial cancer risk with ORs for the highest versus the lowest quartile of 0.69 (95 % CI 0.47–1.00) for FRAP, 0.68 (95 % CI 0.46–0.99) for TEAC, and 0.68 (95 % CI 0.47–0.98) for TRAP. The relations appeared consistent in strata of selected risk factors and decreased when considering TAC without the contribution of coffee. Conclusions: Our findings suggest a favorable role of a diet high in TAC on endometrial cancer risk, which can be partially driven by coffee consumption. © 2016, Springer International Publishing Switzerland.
Συγγραφείς:
Rossi, M.
Tavani, A.
Ciociola, V.
Ferraroni, M.
Parpinel, M.
Serafini, M.
Bellocco, R.
Zucchetto, A.
Montella, M.
Serraino, D.
Lagiou, P.
La Vecchia, C.
Περιοδικό:
Cancer Causes and Control
Εκδότης:
Springer International Publishing
Λέξεις-κλειδιά:
trolox C; antioxidant; coffee, adult; aged; antioxidant activity; Article; caloric intake; cancer risk; case control study; coffee; confidence interval; controlled study; data analysis; disease association; endometrium cancer; female; food composition; food frequency questionnaire; food intake; histopathology; human; Italy; major clinical study; multivariate logistic regression analysis; priority journal; risk assessment; risk factor; risk reduction; adolescent; caloric intake; diet; Endometrial Neoplasms; middle aged; questionnaire; statistical model; young adult, Adolescent; Adult; Aged; Antioxidants; Case-Control Studies; Coffee; Diet; Endometrial Neoplasms; Energy Intake; Female; Humans; Italy; Logistic Models; Middle Aged; Risk Factors; Surveys and Questionnaires; Young Adult
DOI:
10.1007/s10552-016-0719-4
