Τίτλος:
Double KRAS and BRAF mutations in surgically treated colorectal cancer liver metastases: An international, multi-institutional case series
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: While previously believed to be mutually exclusive, concomitant mutation of Kirsten rat sarcoma viral oncogene homolog (KRAS)- and V-raf murine sarcoma b-viral oncogene homolog B1 (BRAF)-mutated colorectal carcinoma (CRC), has been described in rare instances and been associated with advanced-stage disease. The present case series is the first to report on the implications of concurrent KRAS/BRAF mutations among surgically treated patients, and the largest set of patients with surgically treated colorectal liver metastasis (CRLM) and data on KRAS/BRAF mutational status thus far described. Case Series: We present cases from an international, multi-institutional cohort of patients that underwent hepatic resection for CRLM between 2000-2015 at seven tertiary centers. The incidence of KRAS/BRAF mutation in patients with CRLM was 0.5% (4/820). Of these cases, patient 1 (T2N1 primary, G13D/V600E), patient 2 (T3N1 primary, G12V/V600E) and patient 3 (T4N2 primary, G13D/D594N) succumbed to their disease within 485, 236 and 79 days respectively, post-hepatic resection. Patient 4 (T4 primary, G12S/G469S) was alive 416 days after hepatic resection. Conclusion: The present case series suggests that the incidence of concomitant KRAS/BRAF mutations in surgical cohorts may be higher than previously hypothesized, and associated with more variable survival outcomes than expected. © 2018 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Deshwar, A.
Margonis, G.A.
Andreatos, N.
Barbon, C.
Wang, J.
Buettner, S.
Wagner, D.
Sasaki, K.
Beer, A.
Løes, I.M.
Pikoulis, E.
Damaskos, C.
Garmpis, N.
Kamphues, K.
He, J.
Kaczirek, K.
Poultsides, G.
Lønning, P.E.
Mischinger, H.J.
Aucejo, F.N.
Kreis, M.E.
Wolfgang, C.L.
Weiss, M.J.
Περιοδικό:
ANTICANCER RESEARCH
Εκδότης:
International Institute of Anticancer Research
Λέξεις-κλειδιά:
B Raf kinase; fluorouracil; folinic acid; K ras protein; oxaliplatin; B Raf kinase; BRAF protein, human; KRAS protein, human; protein p21, adult; aged; Article; cancer combination chemotherapy; cancer patient; cancer surgery; case study; clinical article; colorectal liver metastasis; disease free interval; gene mutation; human; liver resection; male; middle aged; multicenter study; multiple cycle treatment; priority journal; treatment response; adenocarcinoma; case report; clinical trial; colorectal tumor; female; genetics; liver tumor; mutation; pathology; secondary, Adenocarcinoma; Aged; Colorectal Neoplasms; Female; Humans; Liver Neoplasms; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras)
DOI:
10.21873/anticanres.12535
