Τίτλος:
Cord blood copeptin concentrations in fetal macrosomia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/aim Excessive fetal growth is associated with increased adiposity and reduced insulin sensitivity at birth. Copeptin, a surrogate marker of arginine vasopressin (AVP) secretion, is upregulated in states of hyperinsulinemia and is considered one of the mediators of insulin resistance. We aimed to investigate cord blood concentrations of copeptin (C-terminal fragment of AVP pro-hormone) in healthy large-for-gestational-age (LGA) infants at term. Methods This prospective study was conducted on 30 LGA (n = 30) and 20 appropriate-for-gestational-age (AGA, n = 20) singleton full-term healthy infants. Cord blood copeptin and insulin concentrations were determined by ELISA and IRMA, respectively. Infants were classified as LGA or AGA, based on customized birth-weight standards adjusted for significant determinants of fetal growth. Results Cord blood copeptin concentrations were similar in LGA cases, compared to AGA controls, after adjusting for delivery mode. However, in the LGA group, cord blood copeptin concentrations positively correlated with birth-weight (r = 0.422, p = 0.020). In the AGA group, cord blood copeptin concentrations were elevated in cases of vaginal delivery vs elective cesarean section (p = 0.003). Cord blood insulin concentrations were higher in LGA cases, compared to AGA controls (p = 0.036). No association was recorded between cord blood copeptin concentrations and maternal age, parity, gestational age or fetal gender in both groups. Conclusions Cord blood copeptin concentrations may not be up-regulated in non-distressed LGA infants. However, the positive correlation between cord blood copeptin concentrations and birth-weight in the LGA group may point to the documented association between AVP release and increased fat deposition. Vaginal delivery vs elective cesarean section is accompanied by a marked stress-related increase of cord blood copeptin concentrations. © 2016 Elsevier Inc. All rights reserved.
Συγγραφείς:
Briana, D.D.
Baka, S.
Boutsikou, M.
Boutsikou, T.
Xagorari, M.
Gourgiotis, D.
Malamitsi-Puchner, A.
Περιοδικό:
Metabolism: Clinical and Experimental
Λέξεις-κλειδιά:
copeptin; insulin; AVP protein, human; copeptin; glycopeptide; insulin; neurophysin; protein precursor; vasopressin derivative, Article; birth weight; cesarean section; clinical article; controlled study; elective surgery; enzyme linked immunosorbent assay; female; fetus growth; gestational age; human; immunoradiometric assay; insulin blood level; large for gestational age; lipid storage; macrosomia; male; maternal age; newborn; priority journal; prospective study; protein blood level; protein determination; small for date infant; umbilical cord blood; vaginal delivery; adult; blood; chemistry; fetus blood; fetus development; macrosomia; physiology; pregnancy, Adult; Birth Weight; Female; Fetal Blood; Fetal Development; Fetal Macrosomia; Glycopeptides; Humans; Infant, Newborn; Insulin; Male; Neurophysins; Pregnancy; Prospective Studies; Protein Precursors; Vasopressins
DOI:
10.1016/j.metabol.2015.09.018
