Τίτλος:
Persisting inequalities in survival patterns of childhood neuroblastoma in Southern and Eastern Europe and the effect of socio-economic development compared with those of the US
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: Neuroblastoma outcomes vary with disease characteristics, healthcare delivery and socio-economic indicators. We assessed survival patterns and prognostic factors for patients with neuroblastoma in 11 Southern and Eastern European (SEE) countries versus those in the US, including—for the first time—the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumours (NARECHEM-ST)/Greece. Methods: Overall survival (OS) was calculated in 13 collaborating SEE childhood cancer registries (1829 cases, ∼1990–2016) and Surveillance, Epidemiology, and End Results (SEER), US (3072 cases, 1990–2012); Kaplan–Meier curves were used along with multivariable Cox regression models assessing the effect of age, gender, primary tumour site, histology, Human Development Index (HDI) and place of residence (urban/rural) on survival. Results: The 5-year OS rates varied widely among the SEE countries (Ukraine: 45%, Poland: 81%) with the overall SEE rate (59%) being significantly lower than in SEER (77%; p < 0.001). In the common registration period within SEE (2000–2008), no temporal trend was noted as opposed to a significant increase in SEER. Age >12 months (hazard ratio [HR]: 2.8–4.7 in subsequent age groups), male gender (HR: 1.1), residence in rural areas (HR: 1.3), living in high (HR: 2.2) or medium (HR: 2.4) HDI countries and specific primary tumour location were associated with worse outcome; conversely, ganglioneuroblastoma subtype (HR: 0.28) was associated with higher survival rate. Conclusions: Allowing for the disease profile, children with neuroblastoma in SEE, especially those in rural areas and lower HDI countries, fare worse than patients in the US, mainly during the early years after diagnosis; this may be attributed to presumably modifiable socio-economic and healthcare system performance differentials warranting further research. © 2018 Elsevier Ltd
Συγγραφείς:
Panagopoulou, P.
Georgakis, M.K.
Baka, M.
Moschovi, M.
Papadakis, V.
Polychronopoulou, S.
Kourti, M.
Hatzipantelis, E.
Stiakaki, E.
Dana, H.
Tragiannidis, A.
Bouka, E.
Antunes, L.
Bastos, J.
Coza, D.
Demetriou, A.
Agius, D.
Eser, S.
Gheorghiu, R.
Šekerija, M.
Trojanowski, M.
Žagar, T.
Zborovskaya, A.
Ryzhov, A.
Dessypris, N.
Morgenstern, D.
Petridou, E.T.
Περιοδικό:
EUROPEAN JOURNAL OF CANCER
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
adolescent; age; Article; Belarus; cancer epidemiology; cancer localization; cancer patient; cancer prognosis; cancer registry; cancer survival; central nervous system; child; childhood cancer; clinical outcome; comparative study; Croatia; Cyprus; Eastern Europe; female; Greece; histopathology; human; infant; major clinical study; male; Malta; neuroblastoma; newborn; overall survival; Poland; Portugal; preschool child; primary tumor; priority journal; risk factor; Romania; rural area; sex difference; Slovenia; socioeconomics; Southern Europe; survival rate; trend study; Turkey (republic); Ukraine; United States; urban area; cancer survivor; epidemiology; Europe; health care disparity; health disparity; human development; incidence; mortality; neuroblastoma; onset age; social determinants of health; time factor; treatment outcome; trends, Adolescent; Age of Onset; Cancer Survivors; Child; Child, Preschool; Europe; Female; Health Status Disparities; Healthcare Disparities; Human Development; Humans; Incidence; Infant; Infant, Newborn; Male; Neuroblastoma; Risk Factors; SEER Program; Social Determinants of Health; Socioeconomic Factors; Survival Rate; Time Factors; Treatment Outcome; United States
DOI:
10.1016/j.ejca.2018.03.003
