Τίτλος:
Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Fetal growth restriction (FGR) is a gynecological disorder of varying etiology. In the present study, an expression analysis of pregnancy-associated plasma protein A (PAPPA), pregnancy-associated plasma protein A2 (PAPPA2) and placenta-specific-1 (PLAC-1) was conducted in pregnancies with FGR and control pregnancies. Placental tissues were collected from pregnancies with FGR (n=16) and control pregnancies (n=16) and the expression of the genes of interest was examined by qPCR. The mean expression levels of PAPPA and PAPPA2 were significantly lower (P<0.001) in placental tissues from FGR pregnancies compared with tissues from healthy subjects, whereas the opposite pattern was observed for PLAC-1 (P<0.001). PAPPA and PLAC-1 expression in FGR and control subjects correlated with birth weight (P<0.001). The findings suggest a possible pathophysiological link between the development of FGR and the expression of PAPPA, PAPPA2 and PLAC-1. © 2018 Spandidos Publications. All rights reserved.
Συγγραφείς:
Sifakis, S.
Androutsopoulos, V.P.
Pontikaki, A.
Velegrakis, A.
Papaioannou, G.I.
Koukoura, O.
Spandidos, D.A.
Papantoniou, N.
Περιοδικό:
Molecular Medicine Reports
Εκδότης:
Spandidos Publications
Λέξεις-κλειδιά:
placenta protein; placenta specific 1 protein; pregnancy associated plasma protein A; pregnancy associated plasma protein A2; unclassified drug; PAPPA2 protein, human; PLAC1 protein, human; placenta protein; pregnancy associated plasma protein A, adult; Article; birth weight; clinical article; controlled study; female; gene expression; human; human tissue; intrauterine growth retardation; placenta tissue; pregnancy; biosynthesis; gene expression regulation; intrauterine growth retardation; metabolism; pathology; placenta; pregnancy, Adult; Female; Fetal Growth Retardation; Gene Expression Regulation; Humans; Placenta; Pregnancy; Pregnancy Proteins; Pregnancy-Associated Plasma Protein-A
DOI:
10.3892/mmr.2018.8721
