Περίληψη:
Tumourigenesis is a relatively common event in endocrine tissues. Currently, specific guidelines have been developed for common malignant endocrine tumours, which also incorporate advances in molecular targeted therapies (MTT), as in thyroid cancer and in gastrointestinal neuroendocrine malignancies. However, there is little information regarding the role and efficacy of MTT in the relatively rare malignant endocrine tumours mainly involving the adrenal medulla, adrenal cortex, pituitary, and parathyroid glands. Due to the rarity of these tumours and the lack of prospective studies, current guidelines are mostly based on retrospective data derived from surgical, locoregional and ablative therapies, and studies with systemic chemotherapy. In addition, in many of these malignancies the prognosis remains poor with individual patients responding differently to currently available treatments, necessitating the development of new personalised therapeutic strategies. Recently, major advances in the molecular understanding of endocrine tumours based on genomic, epigenomic, and transcriptome analysis have emerged, resulting in new insights into their pathogenesis and molecular pathology. This in turn has led to the use of novel MTTs in increasing numbers of patients. In this review, we aim to present currently existing and evolving data using MTT in the treatment of adrenal, pituitary and malignant parathyroid tumours, and explore the current utility and effectiveness of such therapies and their future evolution. © 2017 Society for Endocrinology Printed in Great Britain.
Συγγραφείς:
Angelousi, A.
Dimitriadis, G.K.
Zografos, G.
Nölting, S.
Kaltsas, G.
Grossman, A.
Λέξεις-κλειδιά:
(3 iodobenzyl)guanidine i 131; angiogenesis inhibitor; carboxypeptidase H; epidermal growth factor receptor 2; epidermal growth factor receptor kinase inhibitor; heat shock protein 90 inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; hypoxia inducible factor; mammalian target of rapamycin inhibitor; nvp aew451; oxygenase inhibitor; somatostatin receptor; temozolomide; unclassified drug, adrenal cortex carcinoma; adrenal cortex tumor; adrenal medulla tumor; antiproliferative activity; clinical trial (topic); gene expression profiling; hormonal carcinogenesis; human; hypophysis tumor; in vitro study; in vivo study; malignant transformation; molecular therapy; molecularly targeted therapy; paraganglioma; parathyroid carcinoma; parathyroid tumor; pheochromocytoma; practice guideline; Review; adrenal tumor; animal; hypophysis tumor; metabolism; molecularly targeted therapy; paraganglioma; parathyroid tumor; pheochromocytoma, Adrenal Gland Neoplasms; Animals; Humans; Molecular Targeted Therapy; Paraganglioma; Parathyroid Neoplasms; Pheochromocytoma; Pituitary Neoplasms
