Τίτλος:
Elevated Hu-Antigen Receptor (HuR) Expression is Associated with Tumor Aggressiveness and Poor Prognosis but not with COX-2 Expression in Invasive Breast Carcinoma Patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Hu-antigen R (HuR), a RNA-binding protein, is considered to play a crucial role in tumor development and progression by stabilizing or regulating a group of cellular mRNAs of cancer-related genes, such as cyclooxygenase-2 (COX-2). The present study aimed to evaluate the clinical significance of HuR and COX-2 expression in invasive breast carcinoma. HuR and COX-2 protein expression was assessed immunohistochemically on paraffin-embedded breast cancer tissue sections obtained from 121 patients and was statistically analyzed with clinicopathological parameters, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), as well as with tumor cells’ proliferative capacity and overall and disease-free patients’ survival. High HuR expression was positively associated with larger tumor size and advanced disease stage (p = 0.0234 and p = 0.0361, respectively), being more frequently observed in ER negative cases (p = 0.0208). High COX-2 expression was negatively associated with histological (p < 0.0001) and nuclear (p = 0.0033) grade and tumor cells’ proliferative rate (p = 0.0015), being more frequently observed in luminal-A compared to other molecular subtypes (p = 0.0221). High HuR expression was associated with poor overall and disease-free patients’ survival at both univariate (log-rank test, p = 0.0092 and p = 0.0004, respectively) and multivariate (Cox-regression analysis, p = 0.0223 and p = 0.0004, respectively) level. On the other hand, high COX-2 expression was associated with favorable overall and disease-free patients’ survival merely at univariate level (log-rank test, p = 0.0389 and p = 0.0154, respectively). HuR expression was not associated with COX-2 expression (Spearman R = 0.1489, p = 0.1032). The present data support evidence that HuR is associated with tumor aggressiveness and poor prognosis in breast carcinoma, reinforcing its potential as promising therapeutic target in this type of neoplasia. © 2017, Arányi Lajos Foundation.
Συγγραφείς:
Giaginis, C.
Sampani, A.
Kotta-Loizou, I.
Giannopoulou, I.
Danas, E.
Politi, E.
Tsourouflis, G.
Kouraklis, G.
Patsouris, E.
Keramopoulos, A.
Nakopoulou, L.
Theocharis, S.
Περιοδικό:
Pathology and Oncology Research
Εκδότης:
SPRINGER NETHERLANDS
Λέξεις-κλειδιά:
antineoplastic agent; cyclooxygenase 2; ELAV like protein 1; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; cyclooxygenase 2; ELAV like protein 1; ELAVL1 protein, human; PTGS2 protein, human; tumor marker, adjuvant therapy; adult; advanced cancer; aged; Article; breast carcinoma; cancer grading; cancer patient; cancer prognosis; cancer size; cancer staging; cancer survival; cancer tissue; carcinoma cell; cell nucleus; cell proliferation; clinical feature; controlled study; disease activity; disease free survival; estrogen receptor negative breast cancer; female; genetic association; growth rate; histopathology; human; human cell; human tissue; immunohistochemistry; major clinical study; molecular pathology; oncological parameters; overall survival; protein expression; tissue section; tumor invasion; breast tumor; follow up; lobular carcinoma; metabolism; middle aged; Paget nipple disease; pathology; prognosis; survival rate; tumor invasion; very elderly, Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Cyclooxygenase 2; ELAV-Like Protein 1; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasm Invasiveness; Prognosis; Survival Rate
DOI:
10.1007/s12253-017-0288-1
