Τίτλος:
E and P selectins as potential markers in the assessment of the severity of acute pancreatitis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives Acute pancreatitis (AP) is commonly associated with the release of adhesion molecules such as E and P selectins. We designed the present study to evaluate the role of selectins as potential markers that could reflect the severity of the disease. Methods One hundred fifty patients with AP constituted the patient group, whereas 70 healthy volunteers established the control group. In both groups, blood samples were taken for measurements of E selectin, P selectin, caspase-cleaved cytokeratin 18, and total soluble cytokeratin 18 levels on admission and days 1, 2, 4, and 6. Results Values of E and P selectins on admission were both elevated compared with control subjects (P < 0.01). The nonsurvivors had higher values of E selectin (P < 0.04) and P selectin (P < 0.03) on admission. Levels of E and P selectin showed positive correlation with the length of stay (P < 0.05). E selectin on admission yielded a sensitivity of 75% and 78% specificity, whereas P selectin had a sensitivity of 67% and 91% specificity. Conclusions Selectin values in the early course of AP may play a role as indicators of overall prognosis, which may help physicians in better understanding the pathophysiology of a benign disease that may have serious and detrimental complications. © 2018 Wolters Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
Tsaroucha, A.K.
Schizas, D.
Vailas, M.G.
Rachmani, E.
Kanavidis, P.
Asimakopoulos, V.
Vlachos, S.
Sotiropoulou, M.
Pitiakoudis, M.S.
Simopoulos, C.E.
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
C reactive protein; caspase; cytokeratin 18; endothelial leukocyte adhesion molecule 1; PADGEM protein; biological marker; cytokeratin 18; endothelial leukocyte adhesion molecule 1; PADGEM protein, acute pancreatitis; aged; Article; blood sampling; clinical assessment; clinical evaluation; controlled study; cross-sectional study; disease severity; female; hospital admission; human; length of stay; leukocyte count; major clinical study; male; mortality; priority journal; sensitivity and specificity; acute disease; blood; pancreatitis; pathology; severity of illness index; time factor, Acute Disease; Biomarkers; Cross-Sectional Studies; E-Selectin; Humans; Keratin-18; Length of Stay; P-Selectin; Pancreatitis; Patient Admission; Severity of Illness Index; Time Factors
DOI:
10.1097/MPA.0000000000001009
