Περίληψη:
Aim: To examine the real-life impact of baseline positron-emission tomography/computed tomography (PET/CT) in Hodgkin lymphoma (HL). Patients and Methods: A total of 162 consecutive patients with HL were retrospectively studied. Results: Disease was up-staged in 26 patients (16%) and down-staged in 9 (6%). However, treatment strategy was modified in only 10 patients (6% of total). Involved field radiotherapy was delineated according to PET/CT in 36/66 patients (59%). These treatment modifications did not significantly affect outcome. Moreover, three potent prognostic parameters were identified: the number of involved sites, maximum standardized uptake value (SUVmax), and the product of SUVmax and maximal largest lesion diameter, as a surrogate of total lesion glycolysis. All three significantly correlated with 5-year freedom from disease progression p=0.004, p=0.009 and p=0.04, respectively). Conclusion: Baseline PET/CT findings may lead to treatment modification in <15% of patients with HL without a significant impact on outcome. Certain PET/CT parameters have potent prognostic significance.
Συγγραφείς:
Angelopoulou, M.K.
Mosa, E.
Pangalis, G.A.
Rondogianni, P.
Chatziioannou, S.
Prassopoulos, V.
Moschogianni, M.
Tsirkinidis, P.
Asimakopoulos, J.V.
Konstantinou, I.
Tsourouflis, G.
Sachanas, S.
Yiakoumis, X.
Boutsikas, G.
Arapaki, M.
Gainaru, G.
Kyrtsonis, M.-C.
Siakantaris, M.P.
Datseris, I.
Panayiotidis, P.
Konstantopoulos, K.
Vassilakopoulos, T.P.
Λέξεις-κλειδιά:
bleomycin; cyclophosphamide; dacarbazine; doxorubicin; etoposide; fluorodeoxyglucose; prednisone; procarbazine; vinblastine; vincristine, adolescent; adult; advanced cancer; aged; Article; cancer combination chemotherapy; cancer growth; cancer patient; cancer prognosis; cancer radiotherapy; cancer staging; cancer survival; clinical outcome; clinical trial (topic); comparative study; controlled study; decision making; early cancer; female; follow up; glycolysis; Hodgkin disease; human; image reconstruction; imaging software; involved field radiotherapy; major clinical study; male; multiple cycle treatment; overall survival; PET-CT scanner; positron emission tomography-computed tomography; priority journal; retrospective study; cancer staging; diagnostic imaging; disease free survival; Hodgkin disease; Kaplan Meier method; middle aged; mortality; predictive value; procedures; reproducibility; time factor; treatment outcome; very elderly; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Hodgkin Disease; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Positron Emission Tomography Computed Tomography; Predictive Value of Tests; Reproducibility of Results; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult
