Τίτλος:
Sex-specific expression of apolipoprotein levels following replenishment of vitamin D
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Numerous studies have been done to establish the relationship between vitamin D and lipids, yet a definitive causal link is not found. This interventional study aims to evaluate and compare levels of apolipoproteins among vitamin D deficient subjects at baseline and after they achieved full vitamin D status correction.120 Saudi adults with vitamin D deficiency [25(OH)D < 50nmol/l] were recruited and given 50,000IU cholecalciferol weekly for first 2 months, then twice a month for next 2 months, followed by daily 1000IU until month 6. Blood samples were taken at baseline and after 6 months. Serum 25(OH)D, lipid profile and apolipoproteins (A1, A2, B, C1, C2, C3, E and H) were analyzed using commercially available kits. Overall, serum 25(OH)D increased significantly(63.3 ± 16.5nmol/l at end of study vs. 32.5 ± 10.8 at baseline; p < 0.0001). In parallel, a significant increase in apolipoproteins C1, C2, C3 and E (all p-values < 0.01) and a significant decrease in apolipoprotein B (p = 0.02) was observed. Following, stratification according to sex, apolipoproteins C2 and C3 significantly increased only in males (p-values < 0.01) while apolipoprotein C1 significantly increased only in females (p < 0.01). In addition, apolipoprotein B significantly decreased only in females (p = 0.002). These results suggests role of vitamin D in modulation of circulating levels of lipoproteins. The sexual dimorphism observed in circulating levels of measured apolipoproteins following vitamin D correction may explain, in part, known sexual disparity in the events of cardiometabolic health. © 2017 Elsevier Ltd
Συγγραφείς:
Al-Daghri, N.M.
Wani, K.
Sabico, S.
Garbis, S.D.
Chrousos, G.P.
Amer, O.E.
Ansari, M.G.A.
Al-Saleh, Y.
Aljohani, N.J.
Al-Attas, O.S.
Alokail, M.S.
Περιοδικό:
Journal of Steroid Biochemistry and Molecular Biology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
25 hydroxyvitamin D; apolipoprotein; apolipoprotein A1; apolipoprotein A2; apolipoprotein B; apolipoprotein C1; apolipoprotein C2; apolipoprotein C3; apolipoprotein E; beta2 glycoprotein 1; colecalciferol; glucose; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; vitamin D; apolipoprotein; biological marker; vitamin; vitamin D, adult; Article; blood sampling; cardiometabolic risk; cholesterol blood level; female; glucose blood level; human; major clinical study; male; protein expression level; Saudi; sex difference; triacylglycerol blood level; vitamin D deficiency; blood; cardiovascular disease; incidence; Saudi Arabia; sexual characteristics; vitamin D deficiency, Adult; Apolipoproteins; Biomarkers; Cardiovascular Diseases; Female; Humans; Incidence; Male; Saudi Arabia; Sex Characteristics; Vitamin D; Vitamin D Deficiency; Vitamins
DOI:
10.1016/j.jsbmb.2017.12.005
