Τίτλος:
The impact of the metabolic syndrome on bone mass density: A prospective case control study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Obesity and metabolic syndrome (MetS) during the perimenopausal period and in menopause have been linked to altered bone mass density (BMD) in various experimental studies. However, current clinical studies provide conflicting results in this field. The purpose of the present study was to evaluate this association. We conducted a prospective case control study that was based on a consecutive series of menopausal women who attended the Reproductive Endocrinology Outpatient Clinic of our hospital between January 2013 and December 2016. One hundred and forty post-menopausal women were included in the present study. After stratifying the women in two groups according to the presence of MetS we observed that bone turnover markers remained unaffected by the presence of MetS (p > 0.05). On the other hand, both the T- A nd Z-scores of women with MetS were significantly higher compared to healthly postmenopausal women [T-score: 0.4 (-0.7 to 1.3) vs.-1 (-1.62 to-0.1), p < 0.001] [Z-score: 0.55 (-0.3 to 1.7) vs.-0.4 (-1.1 to 0.4), p = 0.003]. According to the findings of our study the presence of MetS during the perimenopausal years seems to have a mild benefit on bone mass density. The pathophysiology that underlies this effect remains unclear as bone turnover markers seem to be unaffected by MetS. © 2018 2018 Walter de Gruyter GmbH, Berlin/Boston.
Συγγραφείς:
Alhazidou, E.
Pergialiotis, V.
Panagopoulos, P.
Chrelias, C.
Hatziagelaki, E.
Papantoniou, N.
Trakakis, E.
Περιοδικό:
Hormone Molecular Biology and Clinical Investigation
Εκδότης:
Walter de Gruyter GmbH
Λέξεις-κλειδιά:
adult; Article; bone density; bone mass; bone turnover; case control study; controlled study; dual energy X ray absorptiometry; female; human; lumbar spine; major clinical study; metabolic syndrome X; osteopenia; osteoporosis; postmenopause; priority journal; prospective study; bone; cross-sectional study; menopause; metabolic syndrome X; metabolism; morphometry; osteoporosis; outpatient; pathology; photon absorptiometry, biological marker, Absorptiometry, Photon; Biomarkers; Body Weights and Measures; Bone and Bones; Bone Density; Case-Control Studies; Cross-Sectional Studies; Female; Humans; Menopause; Metabolic Syndrome; Osteoporosis; Outpatients; Postmenopause
DOI:
10.1515/hmbci-2017-0053
