Τίτλος:
The effect of exercise on coagulation and fibrinolysis factors in patients with peripheral arterial disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Peripheral arterial disease is a widely prevalent atherosclerotic occlusive disorder. Symptoms commence with exercise-induced pain in the lower extremities, known as claudication. Despite the fact that exercise has been shown to improve fibrinolytic profile some patients, the effect of exercise on coagulation and fibrinolysis cascades in claudicants has not been comprehensively defined. Literature search in English language yielded 13 studies of exercise on claudicants, including 420 patients. Claudicants tend to have a higher coagulation activity at rest compared to healthy individuals, a trend that persists even after exercise. Post-exercise coagulation activity of claudicants is increased when compared to their respective baseline levels, but it is so in a non-consistent manner. From the available data, it has been suggested that claudicants have a functional and effective fibrinolytic mechanism in place, operating continuously at a relatively higher activity level compared to healthy individuals. Fibrinolysis seems to be activated by exercise; a positive outcome with a prolonged effect as shown by a few of the studies. A final conclusion whether coagulation or fibrinolysis activity is affected mostly by exercise type and intensity in claudicants could not be answered. All conclusions regarding the effect of exercise on the coagulation and fibrinolysis mechanisms should be taken under cautious consideration, due to the limited number of studies, the small number of patients and the different exercise strategies employed in each study. Further randomized studies with similar exercise protocols could provide safer conclusions in the future. © 2016, © 2016 by the Society for Experimental Biology and Medicine.
Συγγραφείς:
Patelis, N.
Karaolanis, G.
Kouvelos, G.N.
Hart, C.
Metheiken, S.
Περιοδικό:
Experimental Biology and Medicine
Εκδότης:
SAGE Publications Inc.
Λέξεις-κλειδιά:
acetylsalicylic acid; antithrombin III; blood clotting factor; blood clotting factor 13a; cilostazol; plasmin; prothrombin; statin (protein); thrombin; thrombin antithrombin complex; tissue plasminogen activator, ankle brachial index; Article; blood clotting; claudication; enzyme linked immunosorbent assay; exercise; fibrinolysis; human; peripheral occlusive artery disease; quality of life; systematic review; thrombocyte activation; thrombocyte aggregation; blood; blood clotting; exercise; fibrinolysis; pathophysiology; peripheral occlusive artery disease; physiology, Blood Coagulation; Exercise; Fibrinolysis; Humans; Peripheral Arterial Disease
DOI:
10.1177/1535370216660215
