Τίτλος:
Dietary patterns and cardiovascular risk in postmenopausal women: Protocol of a cross-sectional and prospective study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: Aging and menopause are associated with an adverse cardiometabolic profile, predisposing to cardiovascular disease. Diet may also affect their cardiometabolic risk. The aim of this study is to assess dietary habits and patterns of postmenopausal women and their association with adiposity measures, cardiometabolic parameters and subclinical atherosclerosis. Study protocol: The study will include two parts. The first part consists of cross-sectional evaluation of 750 postmenopausal women recruited consecutively from the Menopause Unit of an academic hospital. Dietary intake will be assessed by a food frequency questionnaire. Nutrient and food group intake will be calculated and adherence to the Mediterranean diet and other dietary patterns will be evaluated. A-priori and a-posteriori defined dietary patterns will be tested for associations with major and minor outcome measures. The second part consists of a prospective follow-up of all women recruited at baseline and re-assessment of the same variables after 3 years. Adherence to predefined or a-posteriori defined dietary patterns over these 3 years will be evaluated in association with changes in obesity indices and lipid levels, as well as in the progression of subclinical atherosclerosis. Major outcome measures: Body mass index, lipid profile, carotid and femoral artery intima-media thickness and plaques. Minor outcome measures: Waist circumference, waist-to-hip ratio, abdominal fat layers, incident hypertension and diabetes, homeostasis model assessment of insulin resistance (HOMA-IR), c-reactive protein and markers of subclinical arterial disease, including flow-mediated dilation, pulse wave velocity, augmentation index and ankle-brachial index. Results: The study is expected to complete baseline enrolment by the end of 2018 and follow-up assessment by the end of 2021. The results of the study will address the question of whether dietary patterns and eating habits are associated with cardiometabolic risk as well as with accelerated subclinical arterial disease and arterial aging in postmenopausal women. © 2018 Elsevier B.V.
Συγγραφείς:
Stamatelopoulos, K.
Papavagelis, C.
Augoulea, A.
Armeni, E.
Karagkouni, I.
Avgeraki, E.
Georgiopoulos, G.
Yannakoulia, M.
Lambrinoudaki, I.
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
C reactive protein; high density lipoprotein cholesterol; triacylglycerol, abdominal fat; adult; arterial wall thickness; Article; atherosclerosis; body mass; cardiometabolic risk; cardiovascular risk; carotid artery; controlled study; cross-sectional study; diabetes mellitus; dietary compliance; dietary intake; disease association; female; femoral artery; follow up; food frequency questionnaire; Greece; homeostasis model assessment; human; hypertension; Mediterranean diet; obesity; postmenopause; prospective study; waist circumference; waist hip ratio; anthropometry; cardiovascular disease; feeding behavior; middle aged; obesity, Adiposity; Anthropometry; Cardiovascular Diseases; Cross-Sectional Studies; Feeding Behavior; Female; Humans; Middle Aged; Obesity; Postmenopause; Prospective Studies
DOI:
10.1016/j.maturitas.2018.07.006
