Τίτλος:
Corifollitropin alfa compared with follitropin beta in GnRH-antagonist ovarian stimulation protocols in an unselected population undergoing IVF/ICSI
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Recombinant DNA technologies have produced Corifollitropin alfa (CFa) used during IVF/ICSI in order to keep the circulating FSH levels above the threshold necessary to support multi-follicular growth for a week. In this prospective case-control study, we compared 70 participants treated with 150 μg CFa combined with 150 IU of follitropin beta (study group) with 70 subfertile participants with matching baseline characteristics, conforming with the same inclusion criteria and treated with an antagonist protocol using follitropin beta (control group). Live birth was the primary outcome, while secondary outcome measures were IVF/ICSI cycles characteristics, including adverse events and complications. Live birth was determined in reduced rates in the study compared to the control group, reaching statistical significance [6/70 versus 20/70, p = 0.002], as also in the respective number of clinical pregnancies [9/70 versus 23/70, p = 0.005], although the incidence of miscarriage was similar for both groups [6/70 versus 5/70, p > 0.99]. Most of the secondary parameters examined were similar between groups. Logistic regression revealed that protocol and AFC had a direct impact on live birth. Ovarian stimulation with CFa does not seem to constitute an equally effective method as compared with follitropin beta to be offered in a general subfertile population seeking IVF/ICSI treatments. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Siristatidis, C.
Dafopoulos, K.
Christoforidis, N.
Anifandis, G.
Pergialiotis, V.
Papantoniou, N.
Περιοδικό:
Gynecological Endocrinology
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
cetrorelix; chorionic gonadotropin; corifollitropin alfa; recombinant follitropin; follicle stimulating hormone, human, with HCG C-terminal peptide; follitropin; gonadorelin; recombinant follitropin; recombinant protein, adult; Article; birth rate; case control study; ectopic pregnancy; female; human; in vitro fertilization; infection; intracytoplasmic sperm injection; live birth; major clinical study; multicenter study; outcome assessment; ovary hyperstimulation; pregnancy rate; priority journal; prospective study; spontaneous abortion; antagonists and inhibitors; comparative study; in vitro fertilization; ovulation induction; pregnancy; procedures; young adult, Adult; Case-Control Studies; Female; Fertilization in Vitro; Follicle Stimulating Hormone, Human; Gonadotropin-Releasing Hormone; Humans; Ovulation Induction; Pregnancy; Pregnancy Rate; Recombinant Proteins; Young Adult
DOI:
10.1080/09513590.2017.1323203
