Τίτλος:
DIANA-LncBase: Experimentally verified and computationally predicted microRNA targets on long non-coding RNAs
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Recently, the attention of the research community has been focused on long non-coding RNAs (IncRNAs) and their physiological/pathological implications. As the number of experiments increase in a rapid rate and transcriptional units are better annotated, databases indexing IncRNA properties and function gradually become essential tools to this process. Aim of DIANA-LncBase (www. microrna.gr/LncBase) is to reinforce researchers' attempts and unravel microRNA (miRNA)-IncRNA putative functional interactions. This study provides, for the first time, a comprehensive annotation of miRNA targets on IncRNAs. DIANA-LncBase hosts transcriptome-wide experimentally verified and computationally predicted miRNA recognition elements (MREs) on human and mouse IncRNAs. The analysis performed includes an integration of most of the available IncRNA resources, relevant high-throughput HITS-CLIP and PAR-CLIP experimental data as well as state-of-the-art in silico target predictions. The experimentally supported entries available in DIANA-LncBase correspond to >5000 interactions, while the computationally predicted interactions exceed 10 million. DIANA-LncBase hosts detailed information for each miRNA-IncRNA pair, such as external links, graphic plots of transcripts' genomic location, representation of the binding sites, IncRNA tissue expression as well as MREs conservation and prediction scores. © The Author(s) 2012.
Συγγραφείς:
Paraskevopoulou, M.D.
Georgakilas, G.
Kostoulas, N.
Reczko, M.
Maragkakis, M.
Dalamagas, T.M.
Hatzigeorgiou, A.G.
Περιοδικό:
Nucleic Acids Research
Λέξεις-κλειδιά:
long untranslated RNA; microRNA; RNA binding protein, 5' untranslated region; article; binding site; computer model; controlled study; data base; gene sequence; genetic conservation; human; immunoprecipitation; intron; molecular genetics; mouse; nonhuman; prediction; priority journal; protein analysis; protein cross linking; protein protein interaction; protein targeting; RNA sequence, Animals; Binding Sites; Computational Biology; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Humans; Internet; Mice; MicroRNAs; RNA, Long Untranslated; Sequence Analysis, RNA
