Τίτλος:
Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Autotaxin (ATX) is a member of the nucleotide pyrophosphatase/phosphodiesterase family of ectoenzymes that hydrolyzes phosphodiester bonds of various nucleotides. It possesses lysophospholipase D activity, catalyzing the hydrolysis of lysophosphatidylcholine into lysophosphatidic acid (LPA), and it is considered the major LPA-producing enzyme in the circulation. LPA is a bioactive phospholipid with diverse functions in almost every mammalian cell type, which exerts its action through binding to specific G protein-coupled receptors and stimulates various cellular functions, including migration, proliferation and survival. As a consequence, both ATX and LPA have attracted the interest of researchers, in an effort to understand their roles in physiology and pathophysiology. The present review article aims to summarize the existing knowledge as to the implications of ATX in chronic inflammatory diseases and cancer and to highlight the low molecular weight compounds, which have been developed as leads for the discovery of novel medicines to treat inflammatory diseases and cancer. © 2015 Elsevier Ltd.
Συγγραφείς:
Barbayianni, E.
Kaffe, E.
Aidinis, V.
Kokotos, G.
Περιοδικό:
Progress in Lipid Research
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
1,10 phenanthroline; 2,4 thiazolidinedione derivative; acetal derivative; autotaxin; autotaxin inhibitor; bmp 22; debio 0719; edetic acid; etoposide; fludarabine; gintonin; gri 977143; ha 130; ha 155; ha 219; hydantoin derivative; ki 16198; ki 16425; lysophosphatidic acid; lysophosphatidic acid receptor; oleyl derivative; ono 8430506; paclitaxel; phosphodiesterase inhibitor; phosphonic acid derivative; piperazine derivative; s 32826; sunitinib; unclassified drug; unindexed drug; vpc 8a 202; alkylglycerophosphoethanolamine phosphodiesterase; antiinflammatory agent; antineoplastic agent; phosphodiesterase, antiinflammatory activity; antineoplastic activity; bone metastasis; breast cancer; cardiovascular disease; catalysis; chronic hepatitis; chronic inflammation; diabetes mellitus; drug potency; drug resistance; drug screening; drug structure; drug targeting; embryo development; enzyme specificity; enzyme structure; enzyme substrate; human; IC50; lung fibrosis; lung metastasis; melanoma; metastasis; neoplasm; nonhuman; obesity; pancreas cancer; pathogenesis; priority journal; protein expression; protein function; Review; rheumatoid arthritis; signal transduction; animal; chemistry; chronic disease; inflammation; metabolism; Neoplasms, Mammalia, Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Chronic Disease; Embryonic Development; Humans; Inflammation; Neoplasms; Phosphoric Diester Hydrolases; Substrate Specificity
DOI:
10.1016/j.plipres.2015.02.001
