Τίτλος:
Cytoplasmic mRNA turnover and ageing
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Messenger RNA (mRNA) turnover that determines the lifetime of cytoplasmic mRNAs is a means to control gene expression under both normal and stress conditions, whereas its impact on ageing and age-related disorders has just become evident. Gene expression control is achieved at the level of the mRNA clearance as well as mRNA stability and accessibility to other molecules. All these processes are regulated by cis-acting motifs and trans-acting factors that determine the rates of translation and degradation of transcripts. Specific messenger RNA granules that harbor the mRNA decay machinery or various factors, involved in translational repression and transient storage of mRNAs, are also part of the mRNA fate regulation. Their assembly and function can be modulated to promote stress resistance to adverse conditions and over time affect the ageing process and the lifespan of the organism. Here, we provide insights into the complex relationships of ageing modulators and mRNA turnover mechanisms. © 2015 The Authors.
Συγγραφείς:
Borbolis, F.
Syntichaki, P.
Περιοδικό:
Mechanisms of Ageing and Development
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
cytoplasmic messenger RNA; initiation factor 4E; mammalian target of rapamycin; messenger ribonucleoprotein complex; messenger RNA; microRNA; microRNA let 7; microRNA lin 4; ribonucleoprotein; RNA binding protein; somatomedin C; stress activated protein kinase; transcription factor DAF 16; unclassified drug; messenger RNA, 3' untranslated region; 5' untranslated region; adaptation; adenylation; aging; AU rich element; cellular distribution; DCP2 gene; DCS1 gene; deadenylation; gene; gene expression regulation; genetic association; genetic conservation; GU rich element; human; messenger RNA decay; messenger RNA turnover; molecular dynamics; molecular evolution; nonhuman; P body; priority journal; protein homeostasis; protein synthesis; proteomics; Review; RNA degradation; RNA metabolism; RNA splicing; RNA stability; RNA stress granule; RNA structure; RNA transcription; RNA translation; signal transduction; stress adaptation; aging; animal; cytoplasm; gene expression regulation; metabolism; protein synthesis; RNA stability, Aging; Animals; Cytoplasm; Gene Expression Regulation; Humans; Protein Biosynthesis; RNA Stability; RNA, Messenger
DOI:
10.1016/j.mad.2015.09.006
