Τίτλος:
The role of miRNAs in endometrial cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
miRNAs are small noncoding RNAs that regulate gene expression at the post-transcriptional level. Since their discovery, miRNAs have been associated with every cell function including malignant transformation and metastasis. Endometrial cancer is the most common gynecologic malignancy. However, improvement should be made in interobserver agreement on histological typing and individualized therapeutic approaches. This article summarizes the role of miRNAs in endometrial cancer pathogenesis and treatment. © 2015 Future Medicine Ltd.
Συγγραφείς:
Vasilatou, D.
Sioulas, V.D.
Pappa, V.
Papageorgiou, S.G.
Vlahos, N.F.
Εκδότης:
Future Medicine Ltd
Λέξεις-κλειδιά:
aurora B kinase; cisplatin; decitabine; dicer; DNA methyltransferase 1; DNA methyltransferase 3B; double stranded DNA; microRNA; microRNA 1; microRNA 107; microRNA 141; microRNA 143; microRNA 145; microRNA 15b; microRNA 200; microRNA 200a; microRNA 200b; microRNA 205; microRNA 210; microRNA 223; microRNA 29b; microRNA 429; microRNA 449; Myc protein; protein p53; tamoxifen; tissue inhibitor of metalloproteinase 3; transcription factor AP 2; transcription factor E2F3; transcription factor Twist; unclassified drug; microRNA, antiproliferative activity; Article; cancer cell; cancer chemotherapy; cancer prognosis; cancer radiotherapy; cancer therapy; carcinogenesis; carcinosarcoma; cell function; cell migration; cell motility; chromosome segregation; diagnostic accuracy; DNA methylation; down regulation; drug sensitivity; endometrioid carcinoma; endometrium cancer; endometrium hyperplasia; epithelial mesenchymal transition; gene expression; human; hysterectomy; malignant transformation; metastasis; mitosis; nonhuman; precancer; priority journal; protein expression; tumor suppressor gene; upregulation; Endometrial Neoplasms; female; gene expression regulation; genetics; mortality; pathology; prognosis; RNA interference; treatment outcome, Endometrial Neoplasms; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Prognosis; RNA Interference; Treatment Outcome
