Τίτλος:
In prostate cancer, low adiponectin levels are not associated with insulin resistance
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: Adiponectin, an adipose tissue-derived hormone with insulin-sensitizing effect, has been inversely associated with several hormonally dependent malignancies. Prostate cancer is associated with low levels of adiponectin, which have been proposed as an independent risk factor for this malignancy. Aim of this study was to examine whether hypoadiponectinaemia in prostate is associated with insulin resistance. Experimental Design: Plasma samples and covariate data in the context of a case-control study of 300 Greek men were evaluated including 75 patients with prostate cancer, 75 patients with benign prostatic hyperplasia (BPH) and 150 age-matched healthy controls. Results: Patients with prostate cancer had significantly lower plasma adiponectin levels compared with the other two groups, that is BPH patients and healthy controls (7·4 ± 5 ng/mL vs. 11·5 ± 6·4 ng/mL and 12·8 ± 8 ng/mL, respectively). On the other hand, no statistically significant differences were found between patients with prostate cancer and the other two groups for both HOMA-IR and QUICKI (P-value = 0·551). As expected, in all three groups, the levels of adiponectin correlated negatively with HOMA-IR (rho = -0·214, P-value = 0·006), QUICKI (rho = 0·214, P-value = 0·006) and insulin levels (rho = 0·942, P-value<0·001). Conclusion: In spite of what would have been expected from the relevant literature, our data suggest that the hypoadiponectinaemia in prostatic cancer does not appear to be associated with insulin resistance. © 2015 Stichting European Society for Clinical Investigation Journal Foundation.
Συγγραφείς:
Michalakis, K.
Venihaki, M.
Mantzoros, C.
Vazaiou, A.
Ilias, I.
Gryparis, A.
Margioris, A.N.
Περιοδικό:
European Journal of Clinical Investigation
Λέξεις-κλειδιά:
adiponectin; cholesterol; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; prostate specific antigen; triacylglycerol; adiponectin; ADIPOQ protein, human; biological marker; insulin, adiponectin blood level; adult; age; aged; alcohol consumption; Article; blood level; body mass; case control study; cholesterol blood level; controlled study; glucose blood level; human; insulin blood level; insulin resistance; major clinical study; male; priority journal; prostate cancer; prostate hypertrophy; Quantitative Insulin Sensitivity Check Index; smoking; triacylglycerol blood level; blood; clinical trial; diet restriction; insulin resistance; metabolism; multicenter study; physiology; prostate tumor; regression analysis, Adiponectin; Aged; Biomarkers; Case-Control Studies; Fasting; Humans; Insulin; Insulin Resistance; Male; Prostatic Neoplasms; Regression Analysis
