Τίτλος:
Gene polymorphisms and thyroid function in patients with heart failure
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We evaluated nuclear factor kappa B {NFkB, rs28362491 [-94ins/delATTG (W/D)]} and angiotensin converting enzyme {ACE; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF). Peak oxygen uptake (VO2) was evaluated (by Weber classification) during a symptom-limited cardiopulmonary exercise test in 194 patients. Thyroid-stimulating hormone, triiodothyronine (T3), thyroxine (T4), and free (F) T3 and FT4 were also measured. According to their cardiovascular (CV) capacity, patients were subdivided into four groups: group A included patients with peak VO2 >20 ml/kg/min, group B 16-20 ml/kg/min, group C 10-16 ml/kg/min, and group D 6-10 ml/kg/min. Patients were also genotyped for NFkB and ACE genetic variants. T3 was increased and FT3 was decreased for every raise in Weber's classification (p = 0.007 and p = 0.012, respectively). Del carriers had elevated FT3 levels compared with Ins carriers (p = 0.021). Patients with II genotype had elevated T4 levels compared with ID genotype (p = 0.044). Both T4 and FT4 were decreased in D allele carriers (p = 0.007 and p = 0.045, respectively). Thyroid hormones correlated with CV capacity. Associations between the NFkB and ACE gene polymorphisms and thyroid hormones levels were also observed. Further larger studies are required to clarify genes contribution in HF. © 2013 Springer Science+Business Media New York.
Συγγραφείς:
Vasiliadis, I.
Kolovou, G.
Kolovou, V.
Giannakopoulou, V.
Boutsikou, M.
Katsiki, N.
Papadopoulou, E.
Mavrogeni, S.
Sorontila, K.
Pantos, C.
Cokkinos, D.V.
Περιοδικό:
Endocrine Development
Εκδότης:
Humana Press Inc.
Λέξεις-κλειδιά:
dipeptidyl carboxypeptidase; immunoglobulin enhancer binding protein; liothyronine; thyrotropin; thyroxine, adult; angiotensin converting enzyme gene; article; cardiopulmonary exercise test; clinical evaluation; disease severity; female; gene frequency; genetic association; genetic variability; heart failure; heart volume; hormone determination; human; liothyronine blood level; major clinical study; male; nuclear factor kappa B gene; oxygen consumption; priority journal; single nucleotide polymorphism; thyroid function; thyrotropin blood level; thyroxine blood level, Aged; Cohort Studies; Female; Genotype; Heart Failure; Humans; Male; Middle Aged; NF-kappa B p50 Subunit; Peptidyl-Dipeptidase A; Polymorphism, Genetic; Thyroid Function Tests; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine
DOI:
10.1007/s12020-013-9926-x
