Τίτλος:
Long-term treatment with ramipril favourably modifies the haemostatic response to acute submaximal exercise in hypertensives
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: Hypertension links to a prothrombotic state driven by endothelial dysfunction, reduced fibrinolytic potential and platelet hyperactivity. We hypothesized that ramipril treatment would favourably modify the haemostatic response to a submaximal aerobic exercise session in hypertensives. Methods: Twenty-four hypertensive patients underwent a submaximal exercise test before and after 13±2 months of treatment with ramipril ± hydrochlorothiazide. Hypercoagulability (prothrombin fragments [PF1+2], thrombin- antithrombin complex [TAT] and D-dimers [Dd]), fibrinolytic activity (plasmin-a2-antiplasmin complex [PAP]), endothelial function (von Willebrand factor [vWf] and soluble thrombomodulin [sTM]), and platelet function (soluble P-selectin [sPsel]) were measured before, at peak and one hour after exercise. Results: Antihypertensive treatment resulted in an increase of PAP, vWf and sTM. During the first exercise, PF1+2 were mildly increased at peak exercise (p<0.05), while D-dimers, PAP and vWf varied significantly throughout the exercise (p<0.001). During the second exercise session, PF1+2 were decreased post-exercise (p<0.05), PAP was increased at peak and post-exercise (p<0.001) and vWf was increased at peak (p<0.05) and post-exercise (p<0.001). Conclusions: The haemostatic response to exercise in hypertensives after approximately one year of ramipril treatment is characterized by the attenuated activation of coagulation, enhanced fibrinolysis and endothelial activation. © The Author(s) 2012.
Συγγραφείς:
Galea, V.
Triantafyllidi, H.
Theodoridis, T.
Koutroumbi, M.
Christopoulou-Cokkinou, V.
Kremastinos, D.
Anastasiou-Nana, M.
Lekakis, J.
Περιοδικό:
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System
Λέξεις-κλειδιά:
alpha 2 antiplasmin; antiplasmin; D dimer; hydrochlorothiazide; PADGEM protein; prothrombin; prothrombin fragment 1+2; ramipril; thrombin antithrombin complex; thrombomodulin; unclassified drug; von Willebrand factor, adult; aerobic exercise; antihypertensive therapy; article; blood pressure; clinical article; female; fibrin formation; fibrinolysis; hematological parameters; hemostasis; human; hypercoagulability; hypertension; long term care; male; outcome assessment; thrombocyte function; treatment response; vascular endothelium, acute submaximal exercise; endothelium; Essential hypertension; haemostasis; renin-angiotensin aldosterone system antagonists, Blood Platelets; Blood Pressure; Demography; Endothelium, Vascular; Exercise; Fibrin; Fibrinolysis; Hemostasis; Humans; Hypertension; Male; Middle Aged; Ramipril; Thrombin; Time Factors
DOI:
10.1177/1470320312466125
