Genome-wide association study identifies five new schizophrenia loci

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3089049 88 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Genome-wide association study identifies five new schizophrenia loci
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10 -11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10 -9), ANK3 (rs10994359, P = 2.5 × 10 -8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10 -9). © 2011 Nature America, Inc. All rights reserved.
Έτος δημοσίευσης:
2011
Συγγραφείς:
Ripke, S.
Sanders, A.R.
Kendler, K.S.
Levinson, D.F.
Sklar, P.
Holmans, P.A.
Lin, D.-Y.
Duan, J.
Ophoff, R.A.
Andreassen, O.A.
Scolnick, E.
Cichon, S.
St. Clair, D.
Corvin, A.
Gurling, H.
Werge, T.
Rujescu, D.
Blackwood, D.H.R.
Pato, C.N.
Malhotra, A.K.
Purcell, S.
Dudbridge, F.
Neale, B.M.
Rossin, L.
Visscher, P.M.
Posthuma, D.
Ruderfer, D.M.
Fanous, A.
Stefansson, H.
Steinberg, S.
Mowry, B.J.
Golimbet, V.
De Hert, M.
Jönsson, E.G.
Bitter, I.
Pietiläinen, O.P.H.
Collier, D.A.
Tosato, S.
Agartz, I.
Albus, M.
Alexander, M.
Amdur, R.L.
Amin, F.
Bass, N.
Bergen, S.E.
Black, D.W.
Børglum, A.D.
Brown, M.A.
Bruggeman, R.
Buccola, N.G.
Byerley, W.F.
Cahn, W.
Cantor, R.M.
Carr, V.J.
Catts, S.V.
Choudhury, K.
Cloninger, C.R.
Cormican, P.
Craddock, N.
Danoy, P.A.
Datta, S.
De Haan, L.
Demontis, D.
Dikeos, D.
Djurovic, S.
Donnelly, P.
Donohoe, G.
Duong, L.
Dwyer, S.
Fink-Jensen, A.
Freedman, R.
Freimer, N.B.
Friedl, M.
Georgieva, L.
Giegling, I.
Gill, M.
Glenthøj, B.
Godard, S.
Hamshere, M.
Hansen, M.
Hansen, T.
Hartmann, A.M.
Henskens, F.A.
Hougaard, D.M.
Hultman, C.M.
Ingason, A.
Jablensky, A.V.
Jakobsen, K.D.
Jay, M.
Jürgens, G.
Kahn, R.S.
Keller, M.C.
Kenis, G.
Kenny, E.
Kim, Y.
Kirov, G.K.
Konnerth, H.
Konte, B.
Krabbendam, L.
Krasucki, R.
Lasseter, V.K.
Laurent, C.
Lawrence, J.
Lencz, T.
Lerer, F.B.
Liang, K.-Y.
Lichtenstein, P.
Lieberman, J.A.
Linszen, D.H.
Lönnqvist, J.
Loughland, C.M.
MacLean, A.W.
Maher, B.S.
Maier, W.
Mallet, J.
Malloy, P.
Mattheisen, M.
Mattingsdal, M.
McGhee, K.A.
McGrath, J.J.
McIntosh, A.
McLean, D.E.
McQuillin, A.
Melle, I.
Michie, P.T.
Milanova, V.
Morris, D.W.
Mors, O.
Mortensen, P.B.
Moskvina, V.
Muglia, P.
Myin-Germeys, I.
Nertney, D.A.
Nestadt, G.
Nielsen, J.
Nikolov, I.
Nordentoft, M.
Norton, N.
Nöthen, M.M.
O'Dushlaine, C.T.
Olincy, A.
Olsen, L.
O'Neill, F.A.
Ørntoft, T.F.
Owen, M.J.
Pantelis, C.
Papadimitriou, G.
Pato, M.T.
Peltonen, L.
Petursson, H.
Pickard, B.
Pimm, J.
Pulver, A.E.
Puri, V.
Quested, D.
Quinn, E.M.
Rasmussen, H.B.
Réthelyi, J.M.
Ribble, R.
Rietschel, M.
Riley, B.P.
Ruggeri, M.
Schall, U.
Schulze, T.G.
Schwab, S.G.
Scott, R.J.
Shi, J.
Sigurdsson, E.
Silverman, J.M.
Spencer, C.C.A.
Stefansson, K.
Strange, A.
Strengman, E.
Stroup, T.S.
Suvisaari, J.
Terenius, L.
Thirumalai, S.
Thygesen, J.H.
Timm, S.
Toncheva, D.
Van Den Oord, E.
Van Os, J.
Van Winkel, R.
Veldink, J.
Walsh, D.
Wang, A.G.
Wiersma, D.
Wildenauer, D.B.
Williams, H.J.
Williams, N.M.
Wormley, B.
Zammit, S.
Sullivan, P.F.
O'Donovan, M.C.
Daly, M.J.
Gejman, P.V.
Περιοδικό:
Nature Genetics
Εκδότης:
Nature Publishing Group
Τόμος:
43
Αριθμός / τεύχος:
10
Σελίδες:
969-978
Λέξεις-κλειδιά:
microRNA, article; bipolar disorder; European American; female; gene locus; gene replication; genetic association; genetic identification; genetic transcription; genetic variability; genome analysis; human; intron; major clinical study; male; priority journal; schizophrenia
Επίσημο URL (Εκδότης):
DOI:
10.1038/ng.940
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