Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3089053 43 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 - 10'8 and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits. © 2011 Nature America, Inc. All rights reserved.
Έτος δημοσίευσης:
2011
Συγγραφείς:
Schunkert, H.
König, I.R.
Kathiresan, S.
Reilly, M.P.
Assimes, T.L.
Holm, H.
Preuss, M.
Stewart, A.F.R.
Barbalic, M.
Gieger, C.
Absher, D.
Aherrahrou, Z.
Allayee, H.
Altshuler, D.
Anand, S.S.
Andersen, K.
Anderson, J.L.
Ardissino, D.
Ball, S.G.
Balmforth, A.J.
Barnes, T.A.
Becker, D.M.
Becker, L.C.
Berger, K.
Bis, J.C.
Boekholdt, S.M.
Boerwinkle, E.
Braund, P.S.
Brown, M.J.
Burnett, M.S.
Buysschaert, I.
Carlquist, J.F.
Chen, L.
Cichon, S.
Codd, V.
Davies, R.W.
Dedoussis, G.
Dehghan, A.
Demissie, S.
Devaney, J.M.
Diemert, P.
Do, R.
Doering, A.
Eifert, S.
Mokhtari, N.E.E.
Ellis, S.G.
Elosua, R.
Engert, J.C.
Epstein, S.E.
De Faire, U.
Fischer, M.
Folsom, A.R.
Freyer, J.
Gigante, B.
Girelli, D.
Gretarsdottir, S.
Gudnason, V.
Gulcher, J.R.
Halperin, E.
Hammond, N.
Hazen, S.L.
Hofman, A.
Horne, B.D.
Illig, T.
Iribarren, C.
Jones, G.T.
Jukema, J.W.
Kaiser, M.A.
Kaplan, L.M.
Kastelein, J.J.P.
Khaw, K.-T.
Knowles, J.W.
Kolovou, G.
Kong, A.
Laaksonen, R.
Lambrechts, D.
Leander, K.
Lettre, G.
Li, M.
Lieb, W.
Loley, C.
Lotery, A.J.
Mannucci, P.M.
Maouche, S.
Martinelli, N.
McKeown, P.P.
Meisinger, C.
Meitinger, T.
Melander, O.
Merlini, P.A.
Mooser, V.
Morgan, T.
Mühleisen, T.W.
Muhlestein, J.B.
Münzel, T.
Musunuru, K.
Nahrstaedt, J.
Nelson, C.P.
Nöthen, M.M.
Olivieri, O.
Patel, R.S.
Patterson, C.C.
Peters, A.
Peyvandi, F.
Qu, L.
Quyyumi, A.A.
Rader, D.J.
Rallidis, L.S.
Rice, C.
Rosendaal, F.R.
Rubin, D.
Salomaa, V.
Sampietro, M.L.
Sandhu, M.S.
Schadt, E.
Scḧsignfer, A.
Schillert, A.
Schreiber, S.
Schrezenmeir, J.
Schwartz, S.M.
Siscovick, D.S.
Sivananthan, M.
Sivapalaratnam, S.
Smith, A.
Smith, T.B.
Snoep, J.D.
Soranzo, N.
Spertus, J.A.
Stark, K.
Stirrups, K.
Stoll, M.
Tang, W.H.W.
Tennstedt, S.
Thorgeirsson, G.
Thorleifsson, G.
Tomaszewski, M.
Uitterlinden, A.G.
Van Rij, A.M.
Voight, B.F.
Wareham, N.J.
Wells, G.A.
Wichmann, H.-E.
Wild, P.S.
Willenborg, C.
Witteman, J.C.M.
Wright, B.J.
Ye, S.
Zeller, T.
Ziegler, A.
Cambien, F.
Goodall, A.H.
Cupples, L.A.
Quertermous, T.
Mäsignrz, W.
Hengstenberg, C.
Blankenberg, S.
Ouwehand, W.H.
Hall, A.S.
Deloukas, P.
Thompson, J.R.
Stefansson, K.
Roberts, R.
Thorsteinsdottir, U.
O'Donnell, C.J.
McPherson, R.
Erdmann, J.
Samani, N.J.
Περιοδικό:
Nature Genetics
Εκδότης:
Nature Publishing Group
Τόμος:
43
Αριθμός / τεύχος:
4
Σελίδες:
333-340
Λέξεις-κλειδιά:
article; cardiovascular risk; controlled study; coronary artery disease; Europe; female; gene frequency; gene identification; gene locus; genetic association; genetic susceptibility; genotype; human; major clinical study; male; meta analysis; pathogenesis; pleiotropy; priority journal
Επίσημο URL (Εκδότης):
DOI:
10.1038/ng.784
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