Τίτλος:
TarBase 6.0: Capturing the exponential growth of miRNA targets with experimental support
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
As the relevant literature and the number of experiments increase at a super linear rate, databases that curate and collect experimentally verified microRNA (miRNA) targets have gradually emerged. These databases attempt to provide efficient access to this wealth of experimental data, which is scattered in thousands of manuscripts. Aim of TarBase 6.0 (http://www.microrna.gr/ tarbase) is to face this challenge by providing a significant increase of available miRNA targets derived from all contemporary experimental techniques (gene specific and high-throughput), while incorporating a powerful set of tools in a user-friendly interface. TarBase 6.0 hosts detailed information for each miRNA-gene interaction, ranging from miRNA- and gene-related facts to information specific to their interaction, the experimental validation methodologies and their outcomes. All database entries are enriched with function-related data, as well as general information derived from external databases such as UniProt, Ensembl and RefSeq. DIANA microT miRNA target prediction scores and the relevant prediction details are available for each interaction. TarBase 6.0 hosts the largest collection of manually curated experimentally validated miRNA-gene interactions (more than 65 000 targets), presenting a 16.5-175-fold increase over other available manually curated databases. © The Author(s) 2011. Published by Oxford University Press.
Συγγραφείς:
Vergoulis, T.
Vlachos, I.S.
Alexiou, P.
Georgakilas, G.
Maragkakis, M.
Reczko, M.
Gerangelos, S.
Koziris, N.
Theodore, D.
Hatzigeorgiou, A.G.
Περιοδικό:
Nucleic Acids Research
Λέξεις-κλειδιά:
microRNA, access to information; article; computer interface; controlled study; DIANA; Ensembl; gene interaction; genetic database; high throughput sequencing; human; information processing; Internet; priority journal; protein database; protein function; protein targeting; RefSeq; RNA sequence; TarBase 6.0; UniProt, Data Mining; Databases, Nucleic Acid; Disease; Gene Silencing; Humans; MicroRNAs; User-Computer Interface
