Περίληψη:
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P rs7809799 = 8.81 × 10 -11 and P rs5771069 = 4.21 × 10 -8, respectively). © 2010 Nature America, Inc. All rights reserved.
Συγγραφείς:
Franke, A.
Balschun, T.
Sina, C.
Ellinghaus, D.
Häsler, R.
Mayr, G.
Albrecht, M.
Wittig, M.
Buchert, E.
Nikolaus, S.
Gieger, C.
Wichmann, H.E.
Sventoraityte, J.
Kupcinskas, L.
Onnie, C.M.
Gazouli, M.
Anagnou, N.P.
Strachan, D.
McArdle, W.L.
Mathew, C.G.
Rutgeerts, P.
Vermeire, S.
Vatn, M.H.
Krawczak, M.
Rosenstiel, P.
Karlsen, T.H.
Schreiber, S.
Λέξεις-κλειδιά:
interleukin 17 receptor, article; chromosome 22q; chromosome 7q; controlled study; Europe; gene locus; genome analysis; genotype; human; major clinical study; population genetics; priority journal; risk assessment; single nucleotide polymorphism; ulcerative colitis, Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 7; Colitis, Ulcerative; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Receptors, Interleukin-17; Risk Factors
