Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3089133 58 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-naïve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. © 2010 Elsevier Ltd.
Έτος δημοσίευσης:
2010
Συγγραφείς:
Gattermann, N.
Finelli, C.
Della Porta, M.
Fenaux, P.
Ganser, A.
Guerci-Bresler, A.
Schmid, M.
Taylor, K.
Vassilieff, D.
Habr, D.
Domokos, G.
Roubert, B.
Rose, C.
Agaoglu, L.
Alimena, G.
Alonso, D.
Ame, S.
Angelucci, E.
Arrizabalaga, B.
Athanasiou-Metaxa, M.
Augustson, B.
Aydinok, Y.
Baba, A.
Baccarani, M.
Beck, J.
Beris, P.
Beyne-Rauzy, O.
Birgens, H.
Bordessoule, D.
Borgna-Pignatti, C.
Bosly, A.
Bouabdallah, K.
Bowden, D.
Bowen, D.
Bron, D.
Cappellini, M.D.
Capra, M.
Cartron, G.
Cazzola, M.
Chalkias, C.
Chan, L.L.
Chancharunee, S.
Chapman, C.
Charoenkwan, P.
Chasapopoulou, E.
Cheze, S.
Chuansumrit, A.
Cianciulli, P.
Dauriac, C.
Delforge, M.
Dölken, G.
Dombret, H.
Duyster, J.
Economopoulos, T.
Ehninger, G.
Elalfy, M.
El-Beshlawy, A.
Enggaard, L.
Fillet, G.
Filosa, A.
Forni, G.
Galanello, R.
Gastl, G.
Giraudier, S.
Goldfarb, A.
Grigg, A.
Gumruk, F.
Ha, S.Y.
Haase, D.
Heinrich, B.
Hertzberg, M.
Ho, J.
Hsu, H.-C.
Huang, S.
Hunault-Berger, M.
Inusa, B.
Jaulmes, D.
Jensen, J.
Kattamis, A.
Kilinc, Y.
Kim, K.-H.
Kinsey, S.
Kjeldsen, L.
Koren, A.
Lai, M.E.
Lai, Y.
Lee, J.-W.
Lee, K.-H.
Lee, S.-H.
Legros, L.
Li, C.
Li, C.-K.
Li, Q.
Lin, K.-H.
Linkesch, W.
Lübbert, M.
Lutz, D.
Mohamed Thalha, A.J.
Mufti, G.
Muus, P.
Nobile, F.
Papadopoulos, N.
Perrotta, S.
Petrini, M.
Pfeilstöcker, M.
Piga, A.
Poole, J.
Porter, J.B.
Pungolino, E.
Quarta, G.
Ravoet, C.
Jolimont Lobbes, H.H.
Remacha, A.F.
Roy, L.
Saglio, G.
Sanz, G.
Schmugge, M.
Schots, H.
Secchi, G.
Seymour, J.F.
Shah, F.
Shah, H.
Shen, Z.
Slama, B.
Sutcharitchan, P.
Taher, A.
Tamary, H.
Tesch, H.-J.
Thein, S.L.
Troncy, J.
Villegas, A.
Viprakasit, V.
Wainwright, L.
Wassmann, B.
Wettervald, M.
Will, A.
Wörmann, B.
Wright, J.
Yeh, S.-P.
Yoon, S.-S.
Zoumbos, N.C.
Zweegman, S.
Περιοδικό:
Leukemia Research
Εκδότης:
Elsevier Ireland Ltd
Τόμος:
34
Αριθμός / τεύχος:
9
Σελίδες:
1143-1150
Λέξεις-κλειδιά:
alanine aminotransferase; deferasirox; ferritin; iron, abdominal pain; adolescent; adult; aged; anemia; article; chelation therapy; child; clinical trial; colitis; constipation; creatinine blood level; cytopenia; dementia; diarrhea; dose response; drug dose increase; drug dose reduction; drug efficacy; drug fatality; drug induced headache; drug safety; drug withdrawal; duodenitis; erythrocyte transfusion; esophagitis; female; ferritin blood level; fever; gastritis; gastrointestinal symptom; hearing impairment; heart failure; human; hyperthermia; iron blood level; iron intake; iron overload; leukocyte count; major clinical study; male; multicenter study; myelodysplastic syndrome; neutropenia; pancytopenia; preschool child; priority journal; prospective study; rash; school child; side effect; thrombocytopenia; upper abdominal pain; vomiting; weight reduction
Επίσημο URL (Εκδότης):
DOI:
10.1016/j.leukres.2010.03.009
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