Τίτλος:
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Transformation of normal cells into malignant tumors requires the acquisition of six hallmark traits, e.g., self-sufficiency in growth signals, insensitivity to antigrowth signals and self-renewal, evasion of apoptosis, limitless replication potential, angiogenesis, invasion, and metastasis, which are common to all cancers (Hanahan and Weinberg 2000). These new cellular traits evolve from defects in major regulatory microcircuits that are fundamental for normal homeostasis. The discovery of microRNAs (miRNAs) as a new class of small non-protein-coding RNAs that control gene expression post-transcriptionally by binding to various mRNA targets suggests that these tiny RNA molecules likely act as molecular switches in the extensive regulatory web that involves thousands of transcripts. Most importantly, accumulating evidence suggests that numerous microRNAs are aberrantly expressed in human cancers. In this review, we discuss the emergent roles of microRNAs as switches that function to turn on/off known cellular microcircuits. We outline recent compelling evidence that deregulated microRNAmediated control of cellular microcircuits cooperates with other well-established regulatory mechanisms to confer the hallmark traits of the cancer cell. Furthermore, these exciting insights into aberrant microRNA control in cancer-associated circuits may be exploited for cancer therapies that will target deregulated miRNA switches. Published by Cold Spring Harbor Laboratory Press. Copyright © 2009 RNA Society.
Συγγραφείς:
Sotiropoulou, G.
Pampalakis, G.
Lianidou, E.
Mourelatos, Z.
Περιοδικό:
DNA and RNA Nanotechnology
Λέξεις-κλειδιά:
microRNA, angiogenesis; apoptosis; bladder cancer; breast cancer; cancer cell; cancer diagnosis; cancer growth; cancer invasion; colorectal cancer; deregulation; down regulation; epigenetics; epithelium cell; genetic polymorphism; human; integrated circuit; kidney cancer; mesenchyme cell; metastasis; mutation; nonhuman; Northern blotting; ovary cancer; priority journal; prostate cancer; real time polymerase chain reaction; regulatory mechanism; review; RNA editing; RNA synthesis; RNA transcription; transcription regulation; tumor virus; upregulation; uterine cervix cancer, Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MicroRNAs; Models, Biological; Mutation; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Oncogenic Viruses; RNA Editing; RNA, Neoplasm; Signal Transduction; Telomere
