Περίληψη:
CD40, a transmembrane receptor of the tumor necrosis factor gene superfamily is expressed on a variety of cells, such as monocytes, B-cells, antigen presenting cells, endothelial, smooth muscle cells, and fibroblasts. The interaction between CD40 and CD40 ligand (CD40L) enhances the expression of cytokines, chemokines, matrix metalloproteinases, growth factors, and adhesion molecules, mainly through the stimulation of nuclear factor kappa B. The aim of this review is to summarize the molecular and cellular characteristics of CD40 and CD40L, the mechanisms that regulate their expression, the cellular responses they stimulate and finally their implication in the pathophysiology of inflammatory and autoimmune diseases. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
Συγγραφείς:
Chatzigeorgiou, A.
Lyberi, M.
Chatzilymperis, G.
Nezos, A.
Kamper, E.
Λέξεις-κλειδιά:
CD40 ligand; cell adhesion molecule; chemokine; cytokine; mitogen activated protein kinase, autoimmune disease; priority journal; protein expression; protein interaction; review, Animals; Antigens, CD40; CD40 Ligand; Humans; Models, Biological; Signal Transduction
