Τίτλος:
Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Gestational diabetes mellitus (GDM) and type 2 diabetes (T2D) share common pathophysiological features, including β-cell dysfunction and insulin resistance. In this study, we investigated the association between GDM and five recently identified T2D susceptibility loci, in a Greek population. We studied 148 women with GDM and 107 non-diabetic unrelated pregnant Greek women, for polymorphisms in the TCF7L2 gene (rs7903146 C/T), the PPARG gene (Pro12Ala), the KCNJ11 gene (E23K), the IRS1 gene (G972R) and in the FOXC2 gene (-512C>T). The T-allele of the TCF7L2 rs7903146 (C/T) polymorphism was found to be significantly associated with an increased risk of GDM [p=0.0003; odds ratio (OR) 2.04 (95%CI 1.38-3.00)]. Additionally, CT and TT genotypes were significantly overrepresented in women with GDM compared to controls (p=0.0003 and p=0.0148, respectively). Analysis of the IRS1 G972R polymorphism showed that the R-allele frequency was increased in women with GDM [(p=0.009; OR 1.67 (95%CI 1.14-2.47)]. The genotypes and allele frequencies of the other polymorphisms studied did not statistically differ between the GDM and the control women. Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women. © 2011 Informa UK, Ltd.
Συγγραφείς:
Pappa, K.I.
Gazouli, M.
Economou, K.
Daskalakis, G.
Anastasiou, E.
Anagnou, N.P.
Antsaklis, A.
Περιοδικό:
Gynecological Endocrinology
Λέξεις-κλειδιά:
insulin receptor substrate 1; inwardly rectifying potassium channel subunit Kir6.2; peroxisome proliferator activated receptor gamma 2; transcription factor 7 like 2; transcription factor FOXC2, adult; allele; article; controlled study; DNA polymorphism; female; gene frequency; gene locus; genetic association; genetic predisposition; genetic susceptibility; genotype; human; insulin resistance; major clinical study; non insulin dependent diabetes mellitus; pregnancy diabetes mellitus; priority journal, Adult; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Forkhead Transcription Factors; Genetic Predisposition to Disease; Greece; Humans; Insulin Receptor Substrate Proteins; Insulin Resistance; Phenotype; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; PPAR gamma; Pregnancy; Prospective Studies; Transcription Factor 7-Like 2 Protein; Young Adult
DOI:
10.3109/09513590.2010.490609
