Τίτλος:
Plasticity in human motor cortex is in part genetically determined
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Non-technical summary: Neuronal plasticity refers to the ability of the brain to change in response to different experiences. Plasticity varies between people, but it is not known how much of this variability is due to differences in their genes. In humans, plasticity can be probed by a protocol termed paired associative stimulation and the changes in the motor system that are brought about by such stimulation are thought to be due to strengthening synapses which connect different neurons. We examined pairs of sisters which were either genetically identical (monozygotic) or different (dizygotic). We found that the variability within the monozygotic sister pairs was less than the variability within the dizygotic sister pairs. That plasticity in human motor cortex is in a substantial part genetically determined may be relevant for motor learning and neurorehabilitation, such as after stroke.Abstract Brain plasticity refers to changes in the organization of the brain as a result of different environmental stimuli. The aim of this study was to assess the genetic variation of brain plasticity, by comparing intrapair differences between monozygotic (MZ) and dizygotic (DZ) twins. Plasticity was examined by a paired associative stimulation (PAS) in 32 healthy female twins (9 MZ and 7 DZ pairs, aged 22.6 ± 2.7 and 23.8 ± 3.6 years, respectively). Stimulation consisted of low frequency repetitive application of single afferent electric stimuli, delivered to the right median nerve, paired with a single pulse transcranial magnetic stimulation (TMS) for activation of the abductor pollicis brevis muscle (APB). Corticospinal excitability was monitored for 30 min following the intervention. PAS induced an increase in the amplitudes of the motor evoked potentials (MEP) in the resting APB, compared to baseline. Intrapair differences, after baseline normalization, in the MEP amplitudes measured at 25-30 min post-intervention, were almost double for DZ (1.25) in comparison to MZ (0.64) twins (P= 0.036). The heritability estimate for brain plasticity was found to be 0.68. This finding implicates that genetic factors may contribute significantly to interindividual variability in plasticity paradigms. Genetic factors may be important in adaptive brain reorganization involved in motor learning and rehabilitation from brain injury.Neuronal plasticity refers to the ability of the brain to change in response to different experiences. Plasticity varies between people, but it is not known how much of this variability is due to differences in their genes. In humans, plasticity can be probed by a protocol termed paired associative stimulation and the changes in the motor system that are brought about by such stimulation are thought to be due to strengthening synapses which connect different neurons. We examined pairs of sisters which were either genetically identical (monozygotic) or different (dizygotic). We found that the variability within the monozygotic sister pairs was less than the variability within the dizygotic sister pairs. That plasticity in human motor cortex is in a substantial part genetically determined may be relevant for motor learning and neurorehabilitation, such as after stroke. © 2010 The Authors. Journal compilation © 2010 The Physiological Society.
Συγγραφείς:
Missitzi, J.
Gentner, R.
Geladas, N.
Politis, P.
Karandreas, N.
Classen, J.
Klissouras, V.
Περιοδικό:
JAPANESE JOURNAL OF PHYSIOLOGY
Λέξεις-κλειδιά:
genomic DNA, adult; article; brain depth stimulation; brain function; dizygotic twins; electromyography; evoked muscle response; female; genetic association; genetic variability; genotype; human; human experiment; learning; long term potentiation; monozygotic twins; motor cortex; nerve cell plasticity; nerve excitability; nerve stimulation; neurotransmission; normal human; polymerase chain reaction; priority journal; synapse; transcranial magnetic stimulation, Adult; Analysis of Variance; Brain-Derived Neurotrophic Factor; Electric Stimulation; Electromyography; Evoked Potentials, Motor; Female; Genotype; Humans; Median Nerve; Motor Cortex; Neuronal Plasticity; Questionnaires; Transcranial Magnetic Stimulation
DOI:
10.1113/jphysiol.2010.200600
