Τίτλος:
HOX D13 expression across 79 tumor tissue types
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
HOX genes control normal development, primary cellular processes and are characterized by a unique genomic network organization. Locus D HOX genes play an important role in limb generation and mesenchymal condensation. Dysregulated HOXD13 expression has been detected in breast cancer, melanoma, cervical cancer and astrocytomas. We have investigated the epidemiology of HOXD13 expression in human tissues and its potential deregulation in the carcinogenesis of specific tumors. HOXD13 homeoprotein expression has been detected using microarray technology comprising more than 4,000 normal and neoplastic tissue samples including 79 different tumor categories. Validation of HOXD13 expression has been performed, at mRNA level, for selected tumor types. Significant differences are detectable between specific normal tissues and corresponding tumor types with the majority of cancers showing an increase in HOXD13 expression (16.1% normal vs. 57.7% cancers). In contrast, pancreas and stomach tumor subtypes display the opposite trend. Interestingly, detection of the HOXD13 homeoprotein in pancreas-tissue microarrays shows that its negative expression has a significant and adverse effect on the prognosis of patients with pancreatic cancer independent of the T or N stage at the time of diagnosis. Our study provides, for the first time, an overview of a HOX protein expression in a large series of normal and neoplastic tissue types, identifies pancreatic cancer as one of the most affected by the HOXD13 hoemoprotein and underlines the way homeoproteins can be associated to human cancerogenesis. © 2009 UICC.
Συγγραφείς:
Cantile, M.
Franco, R.
Tschan, A.
Baumhoer, D.
Zlobec, I.
Schiavo, G.
Forte, I.
Bihl, M.
Liguori, G.
Botti, G.
Tornillo, L.
Karamitopoulou-Diamantis, E.
Terracciano, L.
Cillo, C.
Περιοδικό:
International Journal of Cancer
Λέξεις-κλειδιά:
homeobox D13 protein; homeodomain protein; messenger RNA; unclassified drug, adrenal tumor; article; bladder carcinoma; brain tumor; cancer classification; cancer diagnosis; cancer inhibition; cancer patient; cancer staging; cancer tissue; carcinogenesis; controlled study; endometrium tumor; esophagus tumor; gallbladder tumor; gene expression profiling; gene frequency; gene function; human; human tissue; kidney tumor; larynx carcinoma; liver tumor; lung tumor; lymphatic system tumor; mesothelioma; microarray analysis; mouth tumor; neuroendocrine tumor; ovary tumor; pancreas tumor; parathyroid tumor; peripheral nerve tumor; priority journal; prognosis; prostate tumor; protein determination; protein expression; protein function; skin tumor; small intestine tumor; soft tissue tumor; stomach tumor; testis tumor; thymoma; thyroid tumor; tissue microarray; uterus myoma; uterus tumor; vulva carcinoma, Cell Differentiation; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Immunohistochemistry; Kaplan-Meiers Estimate; MicroRNAs; Neoplasms; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Transcription Factors; Tumor Markers, Biological
