Τίτλος:
Clinical significance of ephrin (eph)-a1, -a2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Ephrin (Eph) receptors have been reported to be frequently overexpressed in a wide variety of cancer types, being associated with tumor growth, invasion, metastasis and angiogenesis. The aim of the present study was to evaluate the clinical significance of Eph-A1, -A2, -A4, -A5 and -A7 expression in pancreatic ductal adenocarcinoma. Eph-A1, -A2, -A4, -A5 and -A7 expression and staining intensity were assessed immunohistochemically in tumoral samples of 67 pancreatic adenocarcinoma patients and were statistically analyzed in relation to clinicopathological characteristics, tumor proliferative capacity and patients' survival. Eph receptors were abundantly expressed in pancreatic ductal adenocarcinoma cases examined. Eph-A1 staining intensity was significantly associated with tumor size (pT, p= 0.008) and tumor histopathological stage (pStage, p=0.012). Eph-A2 expression was significantly associated with patients' age (p=0.007), while Eph-A4 and Eph-A5 with tumor proliferative capacity (p=0.019 and p=0.011, respectively). Pancreatic adenocarcinoma patients with moderate/intense Eph-A5 or Eph-A7 staining presented significantly shorter survival times compared to those with negative/mild one (log-rank test, p=0.024 and p=0.009, respectively). Multivariate analysis identified Eph-A5 and Eph-A7 staining intensity as independent prognostic factors (p=0.048 and p=0.004, respectively). In conclusion, the present study revealed that Eph receptors were associated with pancreatic cancer characteristics, supporting evidence for their potential clinical application in management and prognosis of pancreatic adenocarcinoma patients. © Arányi Lajos Foundation 2009.
Συγγραφείς:
Constantinos Giaginis
Tsourouflis, G.
Zizi-Serbetzoglou, A.
Kouraklis, G.
Chatzopoulou, E.
Dimakopoulou, K.
Theocharis, S.E.
Περιοδικό:
Pathology and Oncology Research
Λέξεις-κλειδιά:
ephrin receptor A1; ephrin receptor A2; ephrin receptor A4; ephrin receptor A5; ephrin receptor A7; Ki 67 antigen, adult; age; aged; article; cancer classification; cancer staging; cancer survival; cell proliferation; controlled study; female; gene expression; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; pancreas adenocarcinoma; pancreas resection; prognosis; tumor cell; tumor volume, Aged; Carcinoma, Pancreatic Ductal; Female; Humans; Immunohistochemistry; Kaplan-Meiers Estimate; Male; Neoplasm Staging; Pancreatic Neoplasms; Prognosis; Receptor, EphA1; Receptor, EphA2; Receptor, EphA4; Receptor, EphA5; Receptor, EphA7; Receptors, Eph Family; Tumor Markers, Biological
DOI:
10.1007/s12253-009-9221-6
