Τίτλος:
Ischemia modified albumin, high-sensitivity c-reactive protein and natriuretic peptide in patients with coronary atherosclerosis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Ischemia modified albumin (IMA), is a new biomarker of oxidative processes involved with coronary artery disease (CAD). We determined serum IMA, high-sensitivity C-reactive protein (hsCRP), and natriuretic peptide (NT-proBNP), and evaluated their correlation with severity of coronary atherosclerosis in patients undergoing coronary angiography (CA). Cardiac troponin T (cTnT), CK-MB mass, albumin and Total Antioxidant Status (TAS) were also evaluated. Methods: The study included 114 patients (88 men and 30 women) aged 43-80 years with documented CAD without evidence of acute coronary syndrome undergoing CA and 163 controls (131 men and 32 women) similarly aged. Results: IMA, hsCRP and NT-proBNP were higher (p < 0.001 and p = 0.008 for NT-proBNP) while TAS was lower (p < 0.001) in patients than in controls. IMA and TAS were negatively correlated in all subjects (p < 0.01). Among patients, there was no correlation between IMA and the number of diseased vessels. For CAD diagnosis the best cut-off point for IMA was 101.5 KU/L with a sensitivity and a specificity of 87.7% and a negative predictive value of 83.3%. IMA was associated with an increased risk for CAD (OR = 1.23, 95% CI: 1.16-1.31; p < 0.001). Conclusions: IMA determination may provide earlier information of CAD presence before hsCRP or NT-proBNP elevation, contributing to early assessment of overall patient risk. © 2009 Elsevier B.V. All rights reserved.
Συγγραφείς:
Kazanis, K.
Dalamaga, M.
Nounopoulos, C.
Manolis, A.S.
Sakellaris, N.
Jullien, G.
Dionyssiou-Asteriou, A.
Περιοδικό:
Clinica Chimica Acta
Λέξεις-κλειδιά:
antioxidant; brain natriuretic peptide; C reactive protein; ischemia modified albumin, acute coronary syndrome; adult; age distribution; aged; angiocardiography; article; cardiovascular risk; controlled study; coronary artery atherosclerosis; coronary artery disease; correlation function; early diagnosis; female; human; major clinical study; male; medical documentation; priority journal; sensitivity and specificity; sex difference, Adult; Aged; Aged, 80 and over; Antioxidants; Biological Markers; C-Reactive Protein; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Natriuretic Peptides; Necrosis; Serum Albumin; Troponin T
DOI:
10.1016/j.cca.2009.07.007
