Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3089714 13 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The prognosis of patients with colorectal cancer (CRC) is assessed through conventional clinicopathological parameters, which are not always accurate. Members of the human kallikrein-related peptidases gene family represent potential cancer biomarkers. The aim of this study was to investigate the expression of human tissue kallikrein-related peptidase 6 (KLK6) by immunohistochemistry in CRC to correlate this expression with various histopathological and clinical variables, and to evaluate its significance as a predictor of disease outcome. KLK6 expression was evaluated by immunohistochemistry and an expression score was calculated for each case. In CRC, KLK6 expression was decreased compared to normal colonic mucosa. A statistically significant, positive association was observed between KLK6 and tumor stage (p=0.036), lymph node metastases (p=0.030), and liver metastases (p=0.025). Univariate analysis showed that KLK6 expression and stage had statistically significant correlation with disease-free survival (p=0.045 and p<0.001, respectively) and overall survival (p=0.027 and p<0.001, respectively). Cox multivariate analysis showed that KLK6 expression was an independent predictor of unfavorable overall survival (p=0.041). Kaplan-Meier survival curves showed that KLK6-positive patients have statistically significant lower disease-free and overall survival. In conclusion, KLK6 immunostaining is an independent prognostic marker in patients with CRC. © 2012 Elsevier GmbH.
Έτος δημοσίευσης:
2012
Συγγραφείς:
Petraki, C.
Dubinski, W.
Scorilas, A.
Saleh, C.
Pasic, M.D.
Komborozos, V.
Khalil, B.
Gabril, M.Y.
Streutker, C.
Diamandis, E.P.
Yousef, G.M.
Περιοδικό:
PATHOLOGY RESEARCH AND PRACTICE
Τόμος:
208
Αριθμός / τεύχος:
2
Σελίδες:
104-108
Λέξεις-κλειδιά:
kallikrein 6, adult; aged; article; cancer staging; clinical feature; colon mucosa; colorectal cancer; controlled study; correlation analysis; disease course; disease free survival; female; histopathology; human; human tissue; immunohistochemistry; liver metastasis; lymph node metastasis; major clinical study; male; overall survival; prediction; prognosis; protein expression; scoring system, Adult; Aged; Aged, 80 and over; Carcinoma; Chi-Square Distribution; Colorectal Neoplasms; Disease-Free Survival; Female; Greece; Humans; Immunohistochemistry; Kallikreins; Kaplan-Meier Estimate; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Time Factors; Tumor Markers, Biological
Επίσημο URL (Εκδότης):
DOI:
10.1016/j.prp.2011.12.010
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