Τίτλος:
Diet and expression of estrogen alpha and progesterone receptors in the normal mammary gland
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: It has been recently reported that expression of estrogen alpha (ER-α) and progesterone (PR) receptors in the normal mammary gland is inversely associated with breast cancer risk among postmenopausal women. We investigated whether dietary intakes are associated with the expression of ER-α and PR receptors in the apparently normal, as opposed to pathological, mammary tissue. Methods: In a study in Greece, we examined associations of dietary intakes with ER-α and PR expression in the adjacent-to-pathological apparently normal mammary tissue of 562 women with either breast cancer (267 women) or BBD (299 women). Diet was assessed through an extensive food frequency questionnaire and results were analyzed using multiple logistic regression. Results: Monounsaturated (p = 0.03) and, to a lesser extent, polyunsaturated lipids (p = 0.08) were positively associated with ER-α expression. Cereals and starchy roots were inversely associated with ER-α (p = 0.01), whereas milk and dairy products were inversely associated with PR expression (p = 0.02). Ethanol intake was non-significantly inversely associated with ER-α expression (p = 0.07). Conclusions: Our findings suggest that the weak associations of diet with breast cancer risk could be explained, to some extent, by effects of diet on receptor expression in the normal mammary gland. © 2008 Springer Science+Business Media B.V.
Συγγραφείς:
Lagiou, P.
Samoli, E.
Lagiou, A.
Georgila, C.
Zourna, P.
Barbouni, A.
Gkiokas, G.
Vassilarou, D.
Tsikkinis, A.
Sfikas, C.
Sekeris, C.E.
Hsieh, C.-C.
Adami, H.-O.
Trichopoulos, D.
Περιοδικό:
Cancer Causes and Control
Λέξεις-κλειδιά:
estrogen receptor alpha; polyunsaturated fatty acid; progesterone receptor, adult; aged; alcohol consumption; article; breast cancer; cancer risk; controlled study; dietary intake; female; food intake; human; major clinical study; mammary gland; postmenopause; priority journal; protein expression; questionnaire, Adult; Aged; Breast Neoplasms; Diet; Diet Surveys; Estrogen Receptor alpha; Female; Humans; Logistic Models; Mammary Glands, Human; Middle Aged; Receptors, Progesterone
DOI:
10.1007/s10552-008-9269-8
