Τίτλος:
Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases. © 2011 Informa Healthcare USA, Inc.
Συγγραφείς:
Braoudaki, M.
Katsibardi, K.
Giudicelli, V.
Karamolegou, K.
Papathanassiou, C.
Lefranc, M.-P.
Tzortzatou-Stathopoulou, F.
Περιοδικό:
Cancer Investigation
Λέξεις-κλειδιά:
acute lymphoblastic leukemia; article; cancer diagnosis; cancer relapse; childhood disease; controlled study; gene frequency; gene rearrangement; gene sequence; human; human tissue; immunoglobulin gene; major clinical study; mutational analysis; priority journal; sequence analysis; somatic hypermutation, Biopsy; Bone Marrow Examination; DNA Mutational Analysis; Gene Rearrangement, B-Lymphocyte; Genes, Immunoglobulin; Greece; Humans; Immunoglobulin Variable Region; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Somatic Hypermutation, Immunoglobulin
DOI:
10.3109/07357907.2011.584587
