Τίτλος:
Interleukin-18 in multiple myeloma patients: serum levels in relation to
response to treatment and survival
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Interleukin-18 (IL-18) plays a role in the host’s response to tumours
and angiogenesis. We determined serum levels of IL-18, vascular
endothelial growth factor (VEGF), angiogenin (ANG), tumor necrosis
factor (TNF-alpha) and CRP in 65 newly diagnosed myeloma patients.
IL-18, VEGF, angiogenin, TNF-alpha and CRP were significantly higher at
stage III in comparison to stages 11 and I. These cytokines (measured in
27 patients) significantly decreased after treatment. In survival
analysis, higher levels of IL-18 were associated with a poorer
prognosis. We conclude that increased serum IL-18 in myeloma patients
correlates with advanced disease, increased levels of angiogenic
cytokines and worse survival. (C) 2003 Elsevier Ltd. All rights
reserved.
Συγγραφείς:
Alexandrakis, MG
Passam, FH
Sfiridaki, K
Moschandrea, J and
Pappa, C
Liapi, D
Petreli, E
Roussou, P
Kyriakou, DS
Περιοδικό:
Leukemia Research
Εκδότης:
PERGAMON-ELSEVIER SCIENCE LTD
Λέξεις-κλειδιά:
interleukin-18; multiple myeloma; angiogenesis; proinflammatory
cytokines
DOI:
10.1016/S0145-2126(03)00261-3
