Ερευνητικό υλικό ΕΚΠΑ

Effects of paternal cigarette smoking on testicular function, sperm
fertilizing capacity, embryonic development, and blastocyst capacity for
implantation in rats

Αγγλικά

We evaluated the effects of paternal smoking on testicular function,
sperm fertilizing capacity, embryonic development, and blastocyst
capacity for implantation. Rats of group A were exposed to cigarette
smoke for 10 weeks. Rats of group B were exposed to the smoke of incense
sticks for 10 weeks. Rats of group C served as a control group. Rats of
group D were exposed to cigarette smoke for 7 weeks only. Experimental
period was 10 weeks in all groups. At the end of the experimental period
serum testosterone responses to human chorionic gonadotropin
stimulation, androgen-binding protein activity in testicular cytosols,
epididymal sperm motility, and oocyte fertilization rate, oocyte
cleavage rate, and blastocyst development rate after in vitro
fertilization (IVF) trials were significantly smaller in group A
compared with groups B and C. In contrast, fertilization rate, cleavage
rate, and blastocyst development rate after intracytoplasmic sperm
injection (ICSI) procedures were not significantly different among
groups A, B, C, and D. Both after IVF trials and ICSI techniques, the
proportion of the alive offspring to the number of transferred oocytes
was significantly smaller in group A than in groups B and C. Cigarette
smoke-exposure results in a secretory deficiency of Leydig and Sertoli
cells leading to an impaired epididymal sperm maturation process and
diminished capacity of spermatozoa to penetrate oocytes. In addition
paternal cigarette smoke exposure affects the embryonic ability for
implantation.

2004

Kapawa, A
Giannakis, D
Tsoukanelis, K
Kanakas, N and
Baltogiannis, D
Agapitos, E
Loutradis, D
Miyagawa, I and
Sofikitis, N

Andrologia : Official Journal of Comite International De Andrologia (CIDA)

Wiley

36

2

57-68

blastocyst; cotinine; implantation; paternal smoking; testis

https://doi.org/10.1111/j.1439-0272.2004.00605.x

10.1111/j.1439-0272.2004.00605.x

https://pergamos.lib.uoa.gr/uoa/dl/object/3091055